Translocations as Predictive Biomarkers in Lung Cancer
Inhibitor Study design Response rate Median PFS (months) Median OS (months) Reference Crizotinib Phase 1 57% Not reached n/a Kwak et al. [5] Crizotinib Phase 1 60.8% 9.7 Not reached…
The Molecular Pathology of Lung Cancer: Pre-analytic Considerations
Fig. 6.1 Tissue processing and tumor characteristics involved in specimen adequacy assessment. Tissue processing fixatives and decalcification methods that are suitable for molecular testing are designated with a green check,…
Liquid Biopsies
© Springer International Publishing AG 2018Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier and Eric H. Bernicker (eds.)Precision Molecular Pathology of Lung CancerMolecular Pathology Libraryhttps://doi.org/10.1007/978-3-319-62941-4_21…
Targeted Therapies for Lung Cancer
© Springer International Publishing AG 2018Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier and Eric H. Bernicker (eds.)Precision Molecular Pathology of Lung CancerMolecular Pathology Libraryhttps://doi.org/10.1007/978-3-319-62941-4_19…
Prognostic Biomarkers in Lung Cancer
© Springer International Publishing AG 2018Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier and Eric H. Bernicker (eds.)Precision Molecular Pathology of Lung CancerMolecular Pathology Libraryhttps://doi.org/10.1007/978-3-319-62941-4_18…
Molecular Pathology of Uncommon Carcinomas
Fig. 15.1 Uncommon carcinomas. (a) Sarcomatoid carcinoma , pleomorphic carcinoma type with large cell undifferentiated carcinoma (left) and spindle cell pattern on the right. (b) Sarcomatoid carcinoma, spindle cell type….
Molecular Pathology of Small Cell Carcinoma
© Springer International Publishing AG 2018Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier and Eric H. Bernicker (eds.)Precision Molecular Pathology of Lung CancerMolecular Pathology Libraryhttps://doi.org/10.1007/978-3-319-62941-4_14…
Predictive Biomarkers for Squamous Cell Carcinoma
© Springer International Publishing AG 2018Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier and Eric H. Bernicker (eds.)Precision Molecular Pathology of Lung CancerMolecular Pathology Libraryhttps://doi.org/10.1007/978-3-319-62941-4_13…
Next-Generation and Third-Generation Sequencing of Lung Cancer Biomarkers
Fig. 10.1 Correlation of EGFR mutations and predicted TKI response Next-Generation Sequencing (NGS) Background The clinical use of NGS has significant benefits for diagnostic biomarker discovery and clinical screening capacity compared…
Mutation Testing of Lung Cancer Biomarkers (Excluding IHC and NGS)
Method Sensitivity (% mutant DNA) Application Low sensitivity Sanger sequencing 20% Tumor tissue Medium sensitivity Pyro-sequencing 5–10% Tumor tissue TaqMan PCR 5–10% Tumor tissue SNAPSHOT 5–10% Tumor tissue…
