Exploring ATM and Methylation in Cancer: Emphasizing on Brain Tumors
Fig 6.1 Location of ATM gene on long arm of chromosome 11 ATM gene is, bidirectionally, transcribed and there is an intergenic region spanning 520 bps within this gene which is…
Sentinel Gene Within Cell Territory and Molecular Platforms in Cancer: Methylation Diversity of p53 Gene in Brain Tumors
Fig. 8.1 Localization of p53 gene on chromosome 17p13.2 The origins of p53 gene’s ancestors are initially seen in descendants of single cell choanoflagellates and early metazoan sea anemone. The…
Malignant Rhabdoid Tumor: Epigenetic Mechanism of Tumorogenesis
Fig. 14.1 Cancer associated amino acid substitution of hSNF5 (a) Schematic representation of hSNF5 depicting the two repeats (RPT1 and RPT2) and cancer-associated amino acid substitution mutations. (b) Conservation of…
Molecular and Biological Aspects of Microcephalin Gene: Directions in Brain Tumor and Methylation
Fig. 7.1 Position of MCPH1 gene on chromosome 8p. 7.1.2 MCPH1 Protein BIRT1 (BRCT–repeat inhibitor of human telomerase reverse transcriptase expression) was reported as a repressor of TERT transcription by…
Epigenetics of Thyroid Cancer
Fig. 15.1 RASSF1 chromosome location (The red line on the p arm) Buffy coat sample analysis also displayed an increased promoter hypermethylation of RASSF1A in children with thyroid carcinoma (Wong…
LINE-1 Retrotransposons and Their Role in Cancer
Fig. 3.1 Classes of interspersed repeats with their examples. (termini of the branches, and their taxa of origin in square brackets). For each class their copy number and contribution (%)…
Reciprocal Interconnection of miRNome-Epigenome in Cancer Pathogenesis and Its Therapeutic Potential
Epigenetically regulated miRNAs Location Cancer type Target protein References miR-1–1 & -2 20q13.33 (miR-1-1) 18q11.2 (miR-1-2) Hepatocellular carcinoma FOXP1 MET HDAC4 (Datta et al. 2008) Let-7i 12q14.1 Cholangiocytes TLR4 (O’Hara et al….
Essence of Cancer Epigenetic: A Harmonic Art for the Future
Fig. 17.1 The map of cancer development . (Adopted from P. Mehdipour’s archive) Epigenetic as the result of genes/environmental interaction, through embryonic at the right time and precise direction and…
Biodynamic Phenotypic and Epigenetics Changes of Circulating Tumor Cells: Their Application in Cancer Prognosis and Treatment
Fig. 2.1 Dissemination tumor process. Metastasis process involves the relapse of tumor cells from primary tumor to target organ. This metastasis process is dependent to survival capacity of different subpopulation…
An Introduction to Impact of Bio-Resonance Technology in Genetics and Epigenetics
Fig. 16.1 Schematic diagrams of Bioresonance therapy Bioresonance therapy (BRT) is based upon the knowledge that the entire body is held together at the subatomic level by waves and photons….
