FIGURE 99-1. Interacting feedback loops controlling aldosterone secretion. Volume is regulated through the renin-angiotensin system, and potassium is regulated through direct feedback. A-I, Angiotensin I; A-II, angiotensin II; BP, blood…
With respect to fasting, premeal, or postprandial targets, there is little support for any particular level of glycemic control in the management of type 2 diabetes insofar as no large-scale…
In the remaining 15% of cases, the disease is caused by inborn errors in the molecular steps required for the biosynthesis of thyroid hormones, and generally it is characterized by…
FIGURE 91-1. Schematic representation of the thyroid-stimulating hormone (TSH) receptor. A, The locations of known activating mutations are indicated.B, The nature of the mutations is indicated along with their origins…
FIGURE 133-1. Distribution of normogonadotrophic oligomenorrheic and amenorrheic infertile women who do or do not ovulate after clomiphene citrate (CC) treatment in incremental daily doses of 50, 100, and 150 mg…
RET STRUCTURE AND FUNCTION The RET gene consists of over 20 exons spanning a minimum of 30 kilobases of genomic DNA. The protein product of the gene encodes a cell…
FIGURE 142-1. Pooled summary of contraceptive efficacy from two World Health Organization male contraceptive efficacy studies,4,5 where contraceptive failure rate (pregnancy rate) is plotted against the current sperm concentration in…
FIGURE 16-1. Demonstration of clonality of pituitary adenomas. Southern blots from extracts of gonadotroph adenomas (c lanes) and peripheral leukocytes (d lanes) of five women who were heterozygous for the…
FIGURE 97-1. Outline of regulation and actions of glucocorticoids. See text for details. Normal glucocorticoid levels are regulated in a range and time course that reflect varying physiologic needs as…
Figure 22-1. Anatomic relationship among the pineal gland, hypothalamus, and pituitary gland. The pineal gland also receives parasympathetic and peptidergic innervation originating in the hypothalamus, mesolimbic system, and visual structures….
