Endocrinology: Impact on Science and Medicine

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Endocrinology: Impact on Science and Medicine

FIGURE 1-1. Timeline of selected advances in endocrinology. (ATDs, Antithyroid drugs; CAH, congenital adrenal hyperplasia; DA, dopamine; I-, iodine; OCPs, oral contraceptive pills; Pheo, pheocromocytoma; RAI, radioactive iodine; Rx, treatment;…

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Paget’s Disease of Bone

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Paget’s Disease of Bone

FIGURE 71-1. Radiograph demonstrating osteoporosis circumscripta of the skull affecting the frontal and temporal regions. FIGURE 71-2. Radiograph of an osteolytic lesion of Paget’s disease that began in the diaphysis…

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Development of the Endocrine Pancreas

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Development of the Endocrine Pancreas

FIGURE 31-1. Schematic outline of the development of the mammalian pancreas. 1, Dorsal and ventral buds arise from the duodenal part of the primitive gut endoderm (blackened). 2, The dominant…

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Androgen Physiology, Pharmacology, and Abuse

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Androgen Physiology, Pharmacology, and Abuse

FIGURE 137-1. Pathways of testosterone biosynthesis and action. In men, testosterone biosynthesis occurs almost exclusively in mature Leydig cells by the enzymatic sequences illustrated. Cholesterol originates predominantly by de novo…

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TSH-Producing Adenomas

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on TSH-Producing Adenomas

FIGURE 17-1. The significant increase in reported cases of pituitary thyrotropin (TSH)-producing adenoma in the decade from 1989 to 1999, when ultrasensitive TSH assay and direct methods for free thyroid…

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Hormone Signaling Via G Protein–Coupled Receptors

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Hormone Signaling Via G Protein–Coupled Receptors

FIGURE 5-1. Schematic of G protein–coupled receptor (GPCR) structures. Top panel represents a subclass I rhodopsin/neurotransmitter GPCR. Middle panel represents a subclass II glucagon–related receptor. Bottom panel represents a subclass…

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Adrenocortical Carcinoma

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Adrenocortical Carcinoma

FIGURE 106-1. CT after contrast media of 8.5 cm in homogeneous ACC of the left adrenal gland (white arrow) and liver metastases (black arrows). (Image provided by W. Kenn, Dept….

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Ectopic Hormone Syndromes

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Ectopic Hormone Syndromes

FIGURE 154-1. Dysdifferentiation results in aberrant gene expression. The malignant transformation of a progenitor cell results in a clonal population of cells that have undergone atypical differentiation. These cells share…

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Glucocorticoid Therapy

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Glucocorticoid Therapy

FIGURE 100-1. The structures of commonly used glucocorticoids. In the depiction of cortisol, the 21 carbon atoms of the glucocorticoid skeleton are indicated by numbers, and the four rings are…

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Diabetic Foot and Vascular Complications

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Diabetic Foot and Vascular Complications

FIGURE 55-1. Pathophysiology of the diabetic foot leading to vascular complications. (Modified from LoGerfo FW: Bypass grafts to the dorsalis pedis artery. In Whittemore AD, Bandyk DF, Cronenwett JL, Hertzer…

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