Oncohema Key

Fig. 1 a–d Nanodiamond surfaces possess versatile chemical–physical properties that can mediate potent drug binding and marked improvements in MRI contrast efficiency levels. Reprinted with permission from Nature Publishing Group Furthermore,…

Phase Year initiated Description Cancer indication ClinicalTrials.gov identifier 0 2014 Silica imaging nanoparticle Head and neck, melanoma, prostate, cervical, uterine NCT02106598 0 2014 Magnetic nanoparticle thermoablation Prostate NCT02033447 0 2013…

Fig. 1 Schematic drawing of radiocatalysis by nanoparticles. Exposure of nanoparticles to ionizing radiation (e.g. X-rays) causes Compton and Photoelectric effects—photoelectrons and Auger electrons (e−) are ejected from the nanoparticles as…

Fig. 1 Illustration of the EPR effect depicting the discontinuous epithelium lining blood vessel walls of a tumor with concurrent poor lymphatic drainage compared to normal tissue. Nanoparticles can passively accumulate…

Modality Signal Contrast agent Sensitivity [1] (mol label) Resolution [1] Tissue penetration Risk Primarily morphological/anatomical imaging modalities MRI Magnetic fields Gadolinium, iron oxide nanoparticles 10−9–10−6 50 µm Unlimited Harmless CT X-rays…

Fig. 1 Schematic of some of the mechanisms of endocytosis that have so far been elucidated. The focus in this chapter will be on clathrin-mediated, caveolar-type, macropinocytosis, and phagocytosis mechanisms. Adapted…

Structural feature Examples Composition of particle core Cholesteryl esters [54] Inorganic scaffolds (Au) [89] Shape Discoidal [80] Spherical [89] Protein associated with particle Full-length apoA-I [97] ApoA-I-mimetic peptide [99] ApoE…