Fig. 6.1 Bioactive food components and its integration with various molecular streams in phenotype progression and development Table 6.1 Factors affecting nutrigenomic research and phenotype Approach Definition and factors Transcriptomics…
Gene (description) Function Sample obtained Case # Methy. status Marker Reference 14-3-3-σ/stratifin (SFN) Cell cycle regulation Cell lines, tissue 20 Hyper Therapeutic Ferguson et al. [202] 14-3-3-σ/stratifin (SFN)å Cell cycle…
Fig. 1 Size scale of MNS as compared to biomolecules. MNS can be adapted to include biomolecules, drugs, or targeting and imaging molecules to form targeted MNS theranostic agents Typically, MNS…
Forces Strength Range (nm)* Specificity Main factors vdw forces Weak 0–10 No Interface complementarity H-bond Moderate <0 Partial Hydrogen donor/acceptor at interface Electrostatic forces Moderate 0–10 No Charge state, ionic…
Fig. 1 Structure of a spherical nucleic acid (SNA)—gold nanoparticle conjugate. (Reproduced with permission from [8]) 2.1 Synthesis of SNAs We will first describe how these constructs are synthesized. SNAs can…
Fig. 1 Schematic illustration of the major cellular and noncellular components of the tumor microenvironment (TME). The EPR effect facilitates nanoparticle (NP) accumulation. However, high interstitial fluidic pressure (IFP), pericyte coverage,…
Fig. 1 Different mechanisms of intracellular action of antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs). a Mechanism of action for ASOs, which bind complementary mRNA and cause inhibition of translation…
Fig. 1 a Surfactant-free synthesis of NMOFs [27]. b, c Representative SEM images of NMOFs synthesized by nanoprecipitation (b) [48] and solvothermal method (c) [31]. Reprinted with permission from [27]. Copyright…
Fig. 1 a–d Nanodiamond surfaces possess versatile chemical–physical properties that can mediate potent drug binding and marked improvements in MRI contrast efficiency levels. Reprinted with permission from Nature Publishing Group Furthermore,…
Phase Year initiated Description Cancer indication ClinicalTrials.gov identifier 0 2014 Silica imaging nanoparticle Head and neck, melanoma, prostate, cervical, uterine NCT02106598 0 2014 Magnetic nanoparticle thermoablation Prostate NCT02033447 0 2013…
