Apoptosis and Cancer
Fig. 13.1 Functional classification of cell death modalities as described by the Nomenclature Committee on Cell Death (NCCD) [19] 13.2 Mechanisms of Apoptosis The term “apoptosis” was introduced by Kerr…
The CD95/CD95L Signaling Pathway: A Role in Carcinogenesis
Fig. 9.1 CD95: mRNA to protein Once docked on CD95-DD, FADD self-associates [71] and binds procaspases-8 and procaspases-10, which are auto-processed and released in the cytosol as active caspases, which…
MHC Class I Molecules and Cancer Progression: Lessons Learned from Preclinical Mouse Models
Fig. 10.1 GR9 fibrosarcoma tumor model. Cell clones are adapted to tissue culture from the primary tumor and classified according to MHC-I surface expression The intratumoral heterogeneity in H-2 class…
Nutrition, Immunity, and Cancers
Fig. 20.1 Schematic overview of complex network of diet-immunity-cancer Fig. 20.2 The casual pathways of cachexia occurrence after malignancy It should be noted that antitumor agents with their side effect…
The Role of Exhaustion in Tumor-Induced T Cell Dysfunction in Cancer
Fig. 5.1 T cell activation requires recognition of the antigen and costimulatory signals. Inflammation generated by tissue damage or infections activates antigen-presenting cells (APCs) and stimulates the expression of costimulatory…
Cancer Immunology of Transmissible Cancers
Disease DFTD CTVT Species affected Tasmanian devil Dog, wolf, coyote, jackals, foxes Distribution Tasmania Worldwide Age of origin About 18 years ago At least 6,000 years ago Likely cell of…
Allergies and Cancers
Fig. 21.1 Type I allergic reaction. B B cell, DC dendritic cell, eo eosinophilic granulocyte, IgE immune globulin E, IL interleukin, MC mast cell, Th2 T helper cell type 2,…
Role of Plasmacytoid Dendritic Cells in Cancer
Marker Structure/function Ligand Effect of activation BDCA-2/BDCA-4 Associated with FcεRlγ to form a signaling receptor complex ITAM Upon ligation, they inhibit TLR activation and release of type I IFN CD4…
Immunosenescence, Oxidative Stress, and Cancers
7. Miki C, Kusunoki M, Inoue Y, et al. Remodeling of the immunoinflammatory network system in elderly cancer patients: implications of inflamm-aging and tumor-specific hyperinflammation. Surg Today. 2008;38:873–8.PubMed 8. Vasto…
Primary Immunodeficiencies and Cancers
Gene Disease Inheritance Clinical features Pathogenesis Immune defects Associated cancers ATM (OMIM*607585) Ataxia-telangiectasia AR Cerebellar ataxia, oculocutaneous telangiectasia, chromosomal instability, radiosensitivity, thymic aplasia, recurrent sinopulmonary infections, cancer predisposition (up 40…
