Gene Disease Inheritance Clinical features Pathogenesis Immune defects Associated cancers ATM (OMIM*607585) Ataxia-telangiectasia AR Cerebellar ataxia, oculocutaneous telangiectasia, chromosomal instability, radiosensitivity, thymic aplasia, recurrent sinopulmonary infections, cancer predisposition (up 40…
Fig. 14.1 Autophagy signaling pathway and antitumor therapeutic targets 14.2 Autophagy and Cancer The role of autophagy in cancer is rather perplexing. It is widely postulated that the autophagic pathway…
Fig. 7.1 IL-12 links innate and adaptive antitumor immunity. IL-12 utilizes several mechanisms to induce antitumor effects. IL-27 activates innate effectors, such as NK cells, NKT cells, and γδ −…
© Springer-Verlag Berlin Heidelberg 2015Nima Rezaei (ed.)Cancer Immunology10.1007/978-3-662-44006-3_16 16. Epigenetics and microRNAs in Cancer Petra M. Wise1, 2 , Kishore B. Challagundla1, 2 and Muller Fabbri1, 3 (1) Department of Pediatric Hematology/Oncology, Children’s Center for Cancer and Blood Diseases, Norris…
50. Allavena P, Sica A, Garlanda C, Mantovani A. The yin-yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol Rev. 2008;222:155–61.PubMed 51. Bottazzi B, Polentarutti N, Acero R,…
Fig. 3.1 Role of innate immune receptors in the regulation of antitumor immunity. (a) The functions of the innate immune system are regulated by various receptors expressed in immune cells….
Fig. 6.1 Potential roles of FoxP3+ T cells and Th17 cells in tumors. (a) FoxP3+ T cells are made in the thymus as naïve-type FoxP3+ T cells, which migrate to…
Fig. 2.1 Differentiation pathways of tumor-associated myeloid cells. Myeloid cells originate from hematopoietic stem cells (HSC) in the bone marrow. Here the networks that give rise to the various myeloid…
© Springer-Verlag Berlin Heidelberg 2015Nima Rezaei (ed.)Cancer Immunology10.1007/978-3-662-44006-3_1 1. Introduction on Cancer Immunology and Immunotherapy Nima Rezaei1, 2 , Seyed Hossein Aalaei-Andabili3, 4 and Howard L. Kaufman5 (1) Department of Immunology, Research Center for Immunodeficiencies, Children’s Medical Center, Pediatrics Center…
Fig. 1 The hepatitis B virus genome and the covalently closed circular DNA (cccDNA). The viral genome (left panel) is made of two linear DNA strands maintained in circular configuration by…
