1. Serum LDH > 1.5 times the upper limit of normal 2. Hemoglobin level < lowest limit of normal 3. Corrected serum calcium level > 10 mg/dL (2.5 mmol/L) 4. Interval of less than 1 year…
Chromosomal defect Childhood tumor 1p del, 1p32-p36 del, double minutes Neuroblastoma 11p13 del, trisomy 18 Wilms’ tumor 13q14 del Retinoblastoma Osteosarcoma Trisomy 21 (Down syndrome) Leukemia Monosomy 7 Leukemia and…
Myeloproliferative neoplasms Chronic myelogenous leukemia, BCR-ABL1-positive Chronic neutrophilic leukemia Polycythemia vera Primary myelofibrosis Essential thrombocythemia Chronic eosinophilic leukemia, NOS Mastocytosis Myeloproliferative neoplasm, unclassifiable Myeloid and lymphoid neoplasms with eosinophilia and…
Fig. 5.1 An example of a PTT from Ref. [136]. Eight representative samples from de novo CRCs (T1 → T8), with truncating mutations identified by sequencing analysis. A substantial amount of normal…
Fig. 7.1 HCC evolution and its related molecular and immunological markers. CLD chronic liver disease, RN regenerative nodule, DN dysplastic nodule, N/N nodule-in-nodule [28] 7.4.1 Heat Shock Protein 70 (HSP70)…
Fig. 6.1 Lower esophageal changes seen in Barrett’s esophagitis (BE). Irregular cephalad protrusions of Barrett’s esophagitis gastro-esophageal junction (a). Normal lower esophageal squamous epithelium compared to Barrett’s esophagitis (compare panel…
Fig. 10.1 Low-grade urothelial neoplasm with papillary architecture. Urine cytology specimen stained with Papanicolaou staining (original magnification 400×) Once the initial evaluation and detection with cytology is performed using voided…
Fig. 17.1 The diagnostic algorithm for lymphoid malignancies commonly accepted in daily practice 17.2.1 Molecular Methods Commonly Used in Lymphoid Malignancies 17.2.1.1 Standard Chromosomal Analysis Conventional karyotyping is one of…
Domenico Coppola (ed.)Cancer Growth and ProgressionMolecular Pathology and Diagnostics of Cancer201410.1007/978-94-007-7192-5_16 © Springer Science+Business Media Dordrecht 2014 16. Molecular Pathology and Diagnostics of Cutaneous Malignancy Sudeep Gaudi1, Patricia M. McNab1, Timothy W. McCardle1 and Jane L. Messina1 (1) H. Lee Moffitt…
105. Guo SS, Wu AY, Sawicki MP (2002) Deletion of chromosome 1, but not mutation of MEN-1, predicts prognosis in sporadic pancreatic endocrine tumors. World J Surg 26(7):843–847PubMed 106. Barghorn…
