Graft-Versus-Host Disease and Graft-Versus-Tumor Response Joseph Pidala Frederick L. Locke Claudio Anasetti INTRODUCTION Graft-versus-host disease (GVHD) is the most common treatment complication following hematopoietic stem cell transplantation (HSCT) from an…
Allogeneic Hematopoietic Stem Cell Transplantation (HCT) for Hematologic Malignancies Bipin N. Savani Nishitha M. Reddy Madan Jagasia Haydar Frangoul INTRODUCTION The curative potential of allogeneic hematopoietic stem cell transplantation (HCT)…
Hematopoietic Cell Transplantation Richard A. Nash Vijayakrishna K. Gadi Transplantation of hematopoietic cell grafts containing pluripotent hematopoietic stem cells (HSCs) after myeloablative or nonmyeloablative conditioning regimens reconstitutes immunohematopoiesis. Sites from…
Hematopoietic Stem Cell Transplantation for Nonmalignant Disorders Jacob R. Garcia Mark C. Walters INTRODUCTION Hematopoietic stem cell transplantation (HSCT) has expanded significantly over the past several decades as a consequence…
Waldenström Macroglobulinemia Rafael Fonseca Suzanne R. Hayman Stephen M. Ansell INTRODUCTION Waldenström macroglobulinemia (WM) is a malignancy of mature B cells characterized by a monoclonal IgM in the serum and…
Poems Syndrome, Cryoglobulinemia, and Heavy-Chain Disease Angela Dispenzieri David Dingli Morie A. Gertz INTRODUCTION This chapter addresses three types of immunoglobulin-based orphan diseases: the POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal…
Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis) Morie A. Gertz Martha Q. Lacy Angela Dispenzieri Steven R. Zeldenrust HISTORY The term lardaceous change has … come more into use chiefly through the…
Multiple Myeloma Angela Dispenzieri Martha Q. Lacy Shaji Kumar Multiple myeloma (MM) is a neoplastic plasma cell dyscrasia (PCD) characterized by a clinical pentad: (1) anemia, (2) a monoclonal protein…
Monoclonal Gammopathies of Undetermined Significance and Smoldering Multiple Myeloma S. Vincent Rajkumar Robert A. Kyle John A. Lust INTRODUCTION Nomenclature Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic, pre-malignant…
Molecular Genetic Aspects of Plasma Cell Disorders P. Leif Bergsagel A. Keith Stewart Stephen J. Russell Rafael Fonseca INTRODUCTION Multiple myeloma (MM) is an age-dependent monoclonal tumor of bone marrow…
