Abstract Fetal and neonatal alloimmune thrombocytopenia (AIT) is the most common cause of severe thrombocytopenia in fetuses and neonates [1]. Maternal IgG alloantibodies against paternally derived fetal platelet antigens cross…
Abstract In this chapter, we will focus exclusively on acquired thrombocytopenias that present in the neonatal period. We will discuss the mechanisms underlying some of the most common varieties of…
Abstract Over the last decades, as the survival of neonates admitted to the neonatal intensive care unit (NICU) improved, thrombocytopenia became an increasingly important problem in the care of sick…
Abstract Polycythemia of the newborn is first mentioned in the Bible as Esau and Jacob are described at the time of their birth. Esau appears to be the recipient of…
Abstract This chapter focuses on the recognition and management of hemolysis in newborn infants (). Some of the common hemolytic anemias of childhood first appear in the newborn period, while…
Abstract Hemolytic disease of the fetus and newborn (HDFN) is the immune mediated destruction of fetal and neonatal red blood cells by maternal antibody. HDFN occurs when the fetal red…
Abstract Anemia of prematurity is a multifactorial anemia, characterized by relatively low plasma erythropoietin (EPO) levels, iatrogenic blood loss, low circulating blood volumes and insufficient erythropoiesis. This anemia has been…
Abstract Diagnosing anemia in a neonate is only a first step in a process that includes: clarifying the pathology responsible for the anemia, instituting the best-known therapy (if indeed a…
Abstract The newborn screening (NBS) program is a well-established comprehensive public health initiative with the main goal of identifying newborns affected by genetic disorders, for whom early interventions may prevent…
Abstract Understanding the development of specific components of the neonatal immune system is critical to the understanding of the susceptibility of the neonate to specific pathogens [1]. With the increasing…
