Fig. 15.1 Characteristic features of immature and mature dendritic cells (DCs) Generally, cancer antigens or the long peptides are engulfed by DCs, digested into helper and killer epitope peptides by…
Target antigens Antibody medicines Tumor types Mechanisms of tumor killing Hematopoietic cell differentiation antigens CD20 Rituximab Non-Hodgkin’s lymphoma ADCC Tositumomab Non-Hodgkin’s lymphoma 131I Ibritumomab 90Y CD22 Inotuzumab Non-Hodgkin’s lymphoma Ozogamicin…
Fig. 14.1 Strategy of Wilms’ tumor gene (WT1) product-derived peptide vaccination combined with bacillus Calmette-Guérin cell wall skeleton (BCG-CWS). Intradermally (i.d.) injected BCG-CWS binds to Toll-like receptor (TLR) 2 and 4…
Fig. 19.1 Search for transformation-associated cell surface molecules induced by activated oncogene introduction into murine fetal fibroblasts, rat WFB cells and mouse BALB3T3 cells Meanwhile, as shown in Fig. 19.2,…
Fig. 20.1 Mechanisms for the differential immune status among cancer patients. Balance of the anti-tumor T cell induction pathway and immunosuppressive pathway along with environmental factors may define the differences…
Fig. 3.1 M2 tumor-associated macrophages (TAMs) support tumor growth and progression. Circulating monocytes recruited by tumor-derived chemoattractants develop into TAMs in the tumor microenvironment. TAMs generally show an M2-like phenotype….
Fig. 18.1 Maturation of the antigen-presenting DCs by an adjuvant. Myeloid cells appear to represent the response of innate immunity. Pattern molecules of microbes and denatured self cells behaving like…
Fig. 12.1 Trafficking of nucleic acid-sensing Toll-like receptors (TLRs). To avoid risks of recognizing self-nucleic acids in an extracellular milieu, nucleic acid-sensing TLRs exhibit distinctive intracellular compartmentalization and trafficking. Unc-93…
Fig. 1.1 Accumulation of immature myeloid cells (iMCs) around disseminated cancer cells in the liver. (a) A metastatic focus in the liver stained with hematoxylin and eosin (H&E) (left). Serial…
Fig. 2.1 Schematic drawing of the inflammatory microenvironment in gastrointestinal tumors. The cyclo-oxygenase (COX)-2/prostaglandin (PG) E2 pathway is important for the development and maintenance of the inflammatory microenvironment, including bone…
