Natural Products: Bleomycin and Trabectedin Bruce A. Chabner Natural product research has yielded many active anticancer compounds acting as inhibitors of topoisomerases (Chapter 4) and as antimitotics (Chapter 4). Others,…
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Thyroid Cancer Lori J. Wirth, Tito Fojo Thyroid cancer is the most common endocrine malignancy with an estimated 60,220 cases to be diagnosed in the United States in 2013 (1)….
Adrenocortical Cancer Tito Fojo BACKGROUND AND PRESENTATION Adrenocortical carcinoma (ACC) is a rare malignancy, affecting 1.5–2 persons per million each year (1). ACC is slightly more common in women and…
Antiestrogens Tanja Badovinac Crnjevic, Paul E. Goss ANTIESTROGENS Antiestrogen hormonal therapy is the cornerstone of endocrine treatment of hormone-receptor positive breast cancer. Current antiestrogen treatment options for hormone-receptor positive breast…
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Localized Breast Cancer Beverly Moy Breast cancer is considered “localized” if it is technically possible to excise cancerous tissue, if the tumor does not involve the skin or structures deep…
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