Mantle Cell Lymphoma
Mantle Cell Lymphoma Dan L. Longo Mantle cell lymphoma is neoplasm derived from B cells that normally occupy the mantle zone surrounding the lymphoid follicle. Mantle cell lymphomas account for…
Interferons
Interferons Dan L. Longo The interferons (IFNs) are a family of proteins that are grouped into three classes α, β, and γ. They were discovered based on their ability to…
Chronic Myeloid Leukemia
Chronic Myeloid Leukemia Karen Ballen ETIOLOGY AND EPIDEMIOLOGY Chronic myeloid leukemia (CML) is a clonal disorder of the hematopoietic stem cell affecting every lineage (except T lymphocytes). It affects about…
Antiandrogen Therapy
Antiandrogen Therapy Bruce A. Chabner The initial attempt at treating cancer with hormone ablation was implemented by Charles Huggins at the University of Chicago in 194l, when he hypothesized that…
L-Asparaginase
L-Asparaginase Bruce A. Chabner Most anticancer drugs are small synthetic molecules designed to inhibit enzymes or to interact with DNA. Newer drugs may also be proteins, such as monoclonal antibodies…
