Fig. 10.1 GR9 fibrosarcoma tumor model. Cell clones are adapted to tissue culture from the primary tumor and classified according to MHC-I surface expression The intratumoral heterogeneity in H-2 class…
Fig. 20.1 Schematic overview of complex network of diet-immunity-cancer Fig. 20.2 The casual pathways of cachexia occurrence after malignancy It should be noted that antitumor agents with their side effect…
Fig. 5.1 T cell activation requires recognition of the antigen and costimulatory signals. Inflammation generated by tissue damage or infections activates antigen-presenting cells (APCs) and stimulates the expression of costimulatory…
Disease DFTD CTVT Species affected Tasmanian devil Dog, wolf, coyote, jackals, foxes Distribution Tasmania Worldwide Age of origin About 18 years ago At least 6,000 years ago Likely cell of…
Fig. 21.1 Type I allergic reaction. B B cell, DC dendritic cell, eo eosinophilic granulocyte, IgE immune globulin E, IL interleukin, MC mast cell, Th2 T helper cell type 2,…
7. Miki C, Kusunoki M, Inoue Y, et al. Remodeling of the immunoinflammatory network system in elderly cancer patients: implications of inflamm-aging and tumor-specific hyperinflammation. Surg Today. 2008;38:873–8.PubMed 8. Vasto…
Marker Structure/function Ligand Effect of activation BDCA-2/BDCA-4 Associated with FcεRlγ to form a signaling receptor complex ITAM Upon ligation, they inhibit TLR activation and release of type I IFN CD4…
Gene Disease Inheritance Clinical features Pathogenesis Immune defects Associated cancers ATM (OMIM*607585) Ataxia-telangiectasia AR Cerebellar ataxia, oculocutaneous telangiectasia, chromosomal instability, radiosensitivity, thymic aplasia, recurrent sinopulmonary infections, cancer predisposition (up 40…
Fig. 14.1 Autophagy signaling pathway and antitumor therapeutic targets 14.2 Autophagy and Cancer The role of autophagy in cancer is rather perplexing. It is widely postulated that the autophagic pathway…
Fig. 7.1 IL-12 links innate and adaptive antitumor immunity. IL-12 utilizes several mechanisms to induce antitumor effects. IL-27 activates innate effectors, such as NK cells, NKT cells, and γδ −…
