Abstract Bisphosphonates are osteoclast inhibitors used to treat osteoporosis. In oncology, bisphosphonates are used to prevent or treat skeletal-related events such as pathologic fractures and hypercalcemia of malignancy. In early…
Abstract HER2-positive breast cancer has a distinctive biology, wherein amplification of the HER2 oncogene leads to a cascade of downstream effects. While in the past this distinctive biology was associated…
Abstract As the number of breast cancer survivors increases, more women are at risk for locoregional recurrence of their initial tumor or the growth of a new primary breast cancer….
Abstract Epidemiologic studies demonstrate that, overall, pregnancy is associated with a reduced lifetime risk of developing breast cancer. Yet this protective effect is not constant or immediate. Although uncommon, the…
Abstract Male breast cancer (MBC) is a rare disease, accounting for 1% of all breast cancers. Because of its rarity, it is treated similar to female breast cancer, although important…
Abstract Among breast cancer survivors, a contralateral breast cancer (CBC) is the most frequent second-cancer event, with a reported incidence rate of 0.5% to 1.0% per year. CBC risk is…
Abstract This chapter reviews the pathophysiology, clinical presentation, useful diagnostic studies, and available treatments for breast cancer–associated pericardial disease. Treatment of pericardial involvement in breast cancer is aimed primarily at…
Abstract The cumulative incidence of brain metastasis at 5 years is approximately 5% in patients with breast cancer but is much higher in postmortem autopsy series. Overall breast cancer is…
Abstract Pleural metastases and malignant pleural effusion may occur with metastatic breast cancer. Presentation can vary widely from an incidental finding on imaging to a large effusion with severe dyspnea….
Abstract Endocrine therapy is among the most powerful tools currently available for prevention and treatment of breast cancer, whether in the adjuvant or metastatic setting. Since the “modern” era of…
