Retinoic Acid Receptor-β, From Gene to Clinic
Species Chromosomal location Gene symbol Size Other symbols Human 3p24.2 RARB 423 kb HAP, RRB2, NR1B2, MCOPS12 Mouse 14 A1-A3; 14 7.08 cM Rarb 164 kb Hap, Nr1b2, RARbeta2, A830025K23…
ONCOLOGY
Pathology of Ductal Carcinoma In Situ: Features and Diagnostic Challenges
Fig. 4.1 Gross specimen showing a white pearly irregular tumor with pale yellow gritty areas likely corresponding to comedo necrosis Classic histologic features of DCIS include cohesive, clonal-appearing epithelial cells…
Imaging DCIS: Digital/Film-Screening Mammography, Tomosynthesis, MRI, Ultrasonography
Fig. 3.1 Secretory calcifications present as large rod-like calcifications and are associated with ductal ectasia Fig. 3.2 Milk of calcium is associated with fibrocystic changes. a Cranial caudal view demonstrates…
DCIS and Hereditary Susceptibility for Breast Cancer
Variable BRCA1 BRCA2 Surrounding invasive tumor < Sporadic controls = Sporadic controls Presence in prophylactic mastectomy specimens Increased in women more than 40 years of age Increased in women over 40 years…
Epidemiology of Ductal Carcinoma In Situ
Fig. 1.1 Age-adjusted Surveillance, Epidemiology, and End Results (SEER) incidence rates by age at diagnosis/death; breast (in situ), female, all races, female 1975–2011 (SEER 9; Cancer sites include invasive cases…
Role of Screening Mammography in Early Detection/Outcome of Breast Cancer
RCT RR mortality RR node positive HIP 0.78 0.85 Malmö 0.78 0.83 Two County 0.68 0.73 Edinburgh 0.78 0.81 Stockholm 0.90 0.82 NBSS1 0.97 1.20 NBSS2 1.02 1.09 Gothenburg 0.79…
Introduction, Evolution, and Application of the Van Nuys Prognostic Index in DCIS
© Springer Science+Business Media New York 2015Lisa A. Newman and Jessica M. Bensenhaver (eds.)Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer10.1007/978-1-4939-2035-8_16 16. Introduction, Evolution, and Application of the Van Nuys Prognostic Index in DCIS Aeisha…
Disparities in DCIS Detection and Outcomes Related to Race/Ethnicity
Fig. 17.1 Distribution of racial/ethnic subsets in the general population of women in the USA compared to the distribution of racial-ethnic subsets among women with ductal carcinoma in situ in…
Monitoring and Surveillance Following DCIS Treatment
Fig. 14.1 Baseline and follow-up mammograms in a 51-year-old woman with initial diagnosis of DCIS, treated with breast-conserving surgery and adjuvant radiation. Left breast mammogram at initial diagnosis and at…
Role of Postmastectomy Radiation for DCIS
(1) Department of Radiation Oncology, University of Michigan Health System, 1500 East Medical Center Drive, 48109 Ann Arbor, MI, USA Corey W. Speers Email: rjagsi@med.umich.edu KeywordsDCISMastectomyRadiationLocal recurrenceBreast cancerDecision makingRadiation side…
