Consensus group Definition of negative margin Additional recommendations The American Society of Breast Surgeons [19] No ink on tumor No further surgery if margins > 1 mm, consider re-excision on a case-by-case…
Author Number of patients with DCIS in whom SLN biopsy was performed Number (%) of patients with positive SLN Klauber De More [3] 72 5 (7 %) Wilkie [4] 559 27…
Proliferation genes Ki-67 Higher Ki-67 is seen in poorly differentiated DCIS; an increase in Ki-67 is associated with invasion [22, 23] STYKI5 Loss of overexpression is associated with progression from…
© Springer Science+Business Media New York 2015Lisa A. Newman and Jessica M. Bensenhaver (eds.)Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer10.1007/978-1-4939-2035-8_10 10. Anti-HER2/neu Therapy in DCIS Amelia Tower1 , Ruta D. Rao3 , Kalliopi P. Siziopikou2, 4 , Melody A. Cobleigh3 and…
Year published Patients Years treated Follow-up (months) Local recurrence rate (%) Randomized Non-randomized NSABP B-17 2011 411 1985–1990 206 19.8 (15 years) EORTC 10853 2013 507 1986–1996 128 18…
© Springer Science+Business Media New York 2015Lisa A. Newman and Jessica M. Bensenhaver (eds.)Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer10.1007/978-1-4939-2035-8_8 8. Ductal Carcinoma In Situ Treated with Breast-Conserving Surgery Alone Jessica M. Bensenhaver1 (1) University…
Study Initial biopsy period # cases F/U (years) # subsequent invasive cancers (%) Betsill et al. [11] 1940–1950 10 21.6 6 (60 %) Rosen et al. [10] (expansion of Betsill study)…
© Springer Science+Business Media New York 2015Lisa A. Newman and Jessica M. Bensenhaver (eds.)Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer10.1007/978-1-4939-2035-8_5 5. Molecular Markers in DCIS Theresa L. Schwartz2 and Chelsea Horwood1 (1) Saint Louis University School…
“Good risk” (about 56 % of patients) >90 % survival probability Clinical presentation Low marker profile Non-seminoma Gonadal or retroperitoneal primary tumor and No extrapulmonary visceral metastases AFP < 1,000 ng/ml HCG < 5,000 U/l…
Semen parameter (according to [1]) Testicular cancer patients (n = 563) [2] Patients with Hodgkin lymphoma (n = 474) [3] Normozoospermia 25 % 41 % Oligozoospermia 56 % 56 % Azoospermia 14 % 3…
