Postchemotherapy Retroperitoneal Lymph Node Dissection
Fig. 9.1 (a) Encasement of the infrarenal aorta by mature teratoma (b) extensive and meticulous preparation of the major retroperitoneal vessel: the left renal vein is marked with a blue…
ONCOLOGY
Is There Still an Indication for Primary RPLND in Clinical Stage I Non-seminoma?
Fig. 4.1 Boundaries of template RPLND according to schools. (a) Original full bilateral RPLND. (b) Modified template dissections (right and left) as proposed at Indiana University. (c) Reduced modified template…
What Are the Long-Term Toxicities to Be Controlled and Treated?
Fig. 11.1 Cold-induced Raynaud phenomenon of the fingers in a cisplatin-treated TCSs 11.6 Neurotoxicity Determination of neurotoxicity is a complex task and most precisely performed by neurophysiologic examinations, which are…
What Are the Recent Recommendations for Follow-Up in Testicular Cancer?
Histology Initial stage Therapy Relapse rate (%) Relapse rate >2 years Main area of relapse Reference Seminoma I Surveillance 12–31 3–5 % Abdomen [16–18] 1 % >3 years Seminoma I…
How Should Patients with Recurrent Disease Be Treated Actually?
Conventional–dose chemotherapy (CDCT) VIP Cisplatin 20 mg/m2 Days 1–5 4 cycles Ifosfamide 1.2 g/m2 Days 1–5 Etoposide 75 mg/m2 Days 1–5 TIP Cisplatin 20 mg/m2 Days 1–5 4 cycles Ifosfamide…
Latest Recommendations of the European Germ Cell Cancer Group on Diagnosis and Treatment of Germ Cell Cancer
Localization of the tumour Size Multiplicity Extension of the tumour (pT category according to UICC) Histopathological type (WHO) In seminoma: presence of syncytiotrophoblasts In spermatocytic seminoma: any sarcomatous elements In…
How Should We Treat Clinical Stage I (CSI) Nonseminoma
Treatment Alla LVI + LVI − Surveillanceb BEP × 1c Surveillanceb BEP × 1c Surveillanceb BEP × 1c Number of patients 1,000 1,000 1,000 1,000 1,000 1,000 Relapses 250 21 500 32 150 16 Total number…
Metastatic Germ Cell Cancer: The Intermediate-Prognosis Risk Category
Criteria for intermediate-risk patients by IGCCCG criteria Status Seminoma Nonseminoma Intermediate risk Nonpulmonary visceral metastases present AFP 1,000–10,000 ng/mL Any hCG hCG 5,000–50,000 mU/mL Any LDH LDH 3–10.0 upper limit…
Poor-Prognosis Germ Cell Tumours
Chemotherapy Classification system Number of patients Favourable response rates (%) Progression-free survival (%) Conclusion First author BEP × 4 Indiana University 159 73 61 Double-dose cisplatin not superior and more toxic Nichols…
Is There Still an Indication for Radiotherapy in Seminoma Clinical Stages I–IIA/B?
Treatment option USA (N:261)a (%) Europe (N:969) (%) RAD Chemotherapy Surveillance Several options 62b 3b 21b 19 21 18 42 Vossen et al. [32] Arvold et al. [31] aCompliance rate,…
