Figure 24-1 Schematic illustrations of the types of genome aberrations found in human cancers. 18 Table 24-1 Cancer Gene Census Summary Aberration Type Number of Aberrations Examples of Prominent Affected…
Figure 26-1 Kaplan-Meier analysis of overall survival in 2628 children with newly diagnosed acute lymphocytic leukemia (ALL). The patients participated in 15 consecutive studies conducted at St. Jude Children’s Research…
Figure 20-1 Genomic alterations in glioma co-segregate with only some of the identified molecular subtypes. (With permission from Verhaak RG, Hoadley KA, Purdom E, et al. Integrated genomic analysis identifies…
Figure 5-1 Chromatin surrounding an actively expressed gene in a normal mature cell versus surrounding that same gene when it is DNA hypermethylated and aberrantly, heritably, silenced in a tumor…
Figure 43-1 Schematic illustration of the key intracellular signaling pathways involved in the pathogenesis of differentiated thyroid carcinoma. Figure 43-2 Schematic illustration of the key intracellular signaling pathways involved in…
In addition to these highly penetrant hereditary syndromes, genome-wide association studies are identifying new loci that confer increased risk for either BCC or SCC, although the mechanistic details remain. Single-nucleotide…
Figure 30-1 An outline of the main factors leading from multiple myeloma (MM) to monoclonal gammopathy of undetermined significance (MGUS); the distinction between HD and NHD MM; and finally additional…
Figure 33-1 The Field Cancerization Theory is defined as the presence of one or more mucosal areas consisting of epithelial cells with cancer-associated genetic or epigenetic alterations. A precursor field…
html xmlns=”http://www.w3.org/1999/xhtml”> 52 Cancer Immunotherapy with Vaccines and Checkpoint Blockade Drew Pardoll Therapeutic vaccination for cancer continues to be a major approach to the overall immunotherapy of cancer. Historically, interest…
Figure 42-1 Development of melanoma Although melanomas can develop from melanocytes at the epidermal-dermal junction directly or in a preexisting nevus, an orderly progression from melanocyte to neoplasm (benign nevus)…
