Reference Ranges and Normal Values
Chapter Outline Reference ranges 8 Statistical procedures 9 Confidence limits 9 Normal reference values 10 Physiological variations in the blood count 13 Red cell components 13 Leucocyte count 15 Platelet…
HEMATOLOGY
Collection and Handling of Blood
Chapter Outline Biohazard precautions 1 Procurement of venous blood 1 Equipment 1 Specimen containers 1 Phlebotomy procedure 2 Postphlebotomy procedure 3 Capillary blood 3 Collection of capillary blood 3 Blood…
Polyclonal Polycythemias (Primary and Secondary)
INTRODUCTION Polycythemia, also referred to as erythrocytosis, is characterized by an increased red cell mass. There is no consensus on terminology (ie, primary familial polycythemia but postrenal transplantation erythrocytosis). Polycythemias…
Fragmentation Hemolytic Anemia
DEFINITION Acquired erythrocyte fragmentation occurs when red cells are forced at high shear stress through partial vascular occlusions or over abnormal vascular surfaces. In circumstances in which fragmentation of red…
Drug-Induced Hemolytic Anemia
ETIOLOGY AND PATHOGENESIS Three mechanisms of drug-related immunologic injury to red cells are defined: — Hapten/drug adsorption involving drug-dependent antibodies — Ternary complex formation involving drug-dependent antibodies — Induction of…
Hemolytic Anemia Resulting from Infectious Agents
INTRODUCTION Hemolysis represents a prominent part of the overall clinical picture in many infections. Table 21–1 lists the microorganisms associated with the induction of hemolytic anemia. TABLE 21–1ORGANISMS THAT CAUSE…
Hypersplenism and Hyposplenism
THE SPLEEN The white pulp (lymphoid tissue) functions in antigen processing and antibody production. The red pulp (monocyte-macrophage system) serves as a filter, retaining defective blood cells and foreign particles….
Plasma Cell Disorders
Plasma Cell Disorders Tomer M. Mark, MD Geraldine P. Schechter, MD, MACP Plasma cells are terminally differentiated B cells responsible for immunoglobulin production. Plasma cell disorders represent a group of…
Lymphoproliferative Disorders
Lymphoproliferative Disorders Elizabeth Margolskee, MD, MPH Peter Martin, MD The diagnosis and classification of lymphoid tumors is a multistep process involving integration of clinical, morphologic, phenotypic, and molecular data. The…
Myeloproliferative Neoplasms
Myeloproliferative Neoplasms Olga Pozdnyakova, MD, PhD Attilio Orazi, MD Myeloproliferative neoplasms (MPNs) are a group of clonal disorders of the hematopoietic stem cells that share similar features, such as hypercellular…
