Drug-Induced Hemolytic Anemia





ETIOLOGY AND PATHOGENESIS





  • Three mechanisms of drug-related immunologic injury to red cells are defined:


    — Hapten/drug adsorption involving drug-dependent antibodies


    — Ternary complex formation involving drug-dependent antibodies


    — Induction of autoantibodies that react with red cells in the absence of the inciting drug



  • Drug-related nonimmunologic protein adsorption may also result in a positive direct antiglobulin test without red cell injury.



  • Table 24–1 lists the drugs implicated in the production of a positive direct antiglobulin test and accelerated red cell destruction.



  • Table 24–2 summarizes the four mechanisms of drug-induced immune interaction with the red cell surface.





TABLE 24–1ASSOCIATION BETWEEN DRUGS AND POSITIVE DIRECT ANTIGLOBULIN TESTS*
Jan 8, 2019 | Posted by in HEMATOLOGY | Comments Off on Drug-Induced Hemolytic Anemia
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