Hypersplenism and Hyposplenism





THE SPLEEN





  • The white pulp (lymphoid tissue) functions in antigen processing and antibody production.



  • The red pulp (monocyte-macrophage system) serves as a filter, retaining defective blood cells and foreign particles.




HYPERSPLENISM (INCREASED SPLENIC FUNCTION)





  • Hypersplenism is considered “appropriate” if it is an exaggeration of normal function, as in hereditary spherocytosis or idiopathic thrombocytopenic purpura, or “inappropriate” if the hyperfunction is a result of vascular congestion or infiltrative disease.



  • It is usually associated with splenomegaly.



  • It causes cytopenias with associated compensatory bone marrow hyperplasia.



  • It usually is corrected by splenectomy, if indicated.



  • Table 26–1 lists the causes of hypersplenism. Table 26–2 lists the causes of massive splenomegaly.





TABLE 26–1CLASSIFICATION AND THE MOST COMMON CAUSES OF SPLENOMEGALY AND HYPERSPLENISM
Jan 8, 2019 | Posted by in HEMATOLOGY | Comments Off on Hypersplenism and Hyposplenism
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