Chapter Outline Erythrocytes 439 Red cell antigens 439 Clinical significance of red cell alloantibodies 447 Mechanisms of immune destruction of red cells 448 Antigen–antibody reactions 450 General points of serological…
Chapter Outline Standardisation 533 Reference preparations and control materials 535 Haemoglobin reference preparations 535 Quality control preparations 536 Quality assurance procedures 536 Internal quality control procedures 537 Control charts 537…
Chapter Outline Introduction: types of laboratories 547 Organisation of clinical laboratory services 547 Level 1: primary and subdistrict laboratories 548 Level 2: intermediate (district) level laboratories 548 Level 3: regional…
Chapter Outline Common presentations of haematological diseases 497 Initial screening tests 497 Quantitative abnormalities of blood cells 498 Qualitative abnormalities of blood cells 502 Specific tests for common haematological disorders…
Chapter Outline Principles of flow cytometric immunophenotyping 330 Multicolour flow cytometric immunophenotyping 331 Methods 332 Detection of membrane antigens 333 Detection of surface immunoglobulin 334 Detection of intracellular antigens 335…
Chapter Outline Oral anticoagulant treatment using vitamin K antagonists 426 Standardisation of oral anticoagulant treatment 426 Calibration of thromboplastins 426 Local calibration of thromboplastins and direct INR determination 428 Determination…
Chapter Outline The haemoglobin molecule 283 Structural variants of haemoglobin 284 Haemoglobins with reduced solubility 284 Unstable haemoglobins 285 Haemoglobins with altered oxygen affinity 285 Haemoglobin M 285 Thalassaemia syndromes…
Chapter Contents Management structure and function 512 Staff appraisal 512 Continuing professional development 513 Strategic and business planning 513 Test reliability 515 Test selection 516 Test utility 516 Instrumentation 517…
Chapter Outline Introduction to thrombophilia 410 Pre-analytical factors 411 Tests for the presence of a lupus anticoagulant 411 Dilute Russell’s viper venom time 412 Platelet neutralisation test 413 Kaolin clotting…
Chapter Outline Investigation of membrane defects 229 Osmotic fragility as measured by lysis in hypotonic saline 229 Osmotic fragility after incubating the blood at 37 °C for 24 H 230…
