Chapter Outline HISTORY AND OVERVIEW CONDITIONING REGIMENS SOURCES OF STEM CELLS Allogeneic Stem Cell Transplantation Autologous Stem Cell Transplantation PERITRANSPLANT SUPPORTIVE CARE Transfusion Support Nutrition Support Infection Prophylaxis and Treatment…
Chapter Outline HISTORY PHYLOGENY MARROW ANATOMY HEMATOPOIETIC CELLS Stem Cells Progenitor Cells Precursors and Mature Cells THE HEMATOPOIETIC GROWTH FACTORS The Lymphohematopoietic Cytokines The Receptor Tyrosine Kinase Ligands The Interleukin…
Chapter Outline APLASTIC ANEMIA Epidemiology Causal Factors Pathophysiology Clinical Evaluation Management and Outcome PURE RED CELL APLASIA Primary Acquired Pure Red Cell Aplasia Secondary Acquired Pure Red Cell Aplasia Acquired…
Chapter Outline HISTORICAL ASPECTS THE Rh BLOOD GROUP SYSTEM Biochemistry and Molecular Genetics RhD ALLOIMMUNIZATION Maternal Rh Sensitization The Nature of Rh Sensitization Pathogenesis of Rh Hemolytic Disease SEVERITY OF…
Chapter Outline ONTOGENY OF THE HUMAN HEMOSTATIC SYSTEM Coagulation Factors Natural Inhibitors of Coagulation Vitamin K–Dependent Factors The Fetal and Neonatal Fibrinolytic System D-Dimers von Willebrand Factor Platelets Blood Vessel…
Chapter Outline INTRODUCTION THE NEONATAL ERYTHROCYTE NORMAL HEMATOLOGIC VALUES NEONATAL ANEMIA HEMORRHAGE IN THE FETUS AND NEWBORN Prenatal Hemorrhage Intrapartum Hemorrhage Postpartum Hemorrhage Clinical Manifestations of Fetal and Neonatal Hemorrhage…
Chapter Outline Examination of blood films 62 Red cell morphology 62 Abnormal erythropoiesis 63 Anisocytosis (ανισοζ, unequal) and poikilocytosis (ποικιλοζ, varied) 63 Macrocytes 65 Microcytes 65 Basophilic stippling 66 Inadequate…
Chapter Outline Erythrocyte cytochemistry 312 Siderocytes and sideroblasts 312 Haemoglobin derivatives 315 Leucocyte cytochemistry 317 Myeloperoxidase 318 Sudan Black B 319 Neutrophil alkaline phosphatase 319 Acid phosphatase reaction, including tartrate-resistant…
Chapter Outline Components of normal haemostasis 367 The blood vessel 367 Platelets 368 Blood coagulation 369 Inhibitors of coagulation 372 The fibrinolytic system 372 General approach to investigation of haemostasis…
Chapter Outline Technology and automation in blood transfusion laboratories 472 Pretransfusion compatibility systems 473 Documentation of the transfusion process 474 Blood samples and their storage requirements 474 Quality assurance in…
