© Springer-Verlag London 2015Hannah Cohen and Patrick O’Brien (eds.)Disorders of Thrombosis and Hemostasis in Pregnancy10.1007/978-3-319-15120-5_23 23. Thrombotic and Hemostatic Aspects of Assisted Conception Irfana Koita-Kazi1 , Maria Efthymiou2 , Hannah Cohen3 and Paul Serhal1 (1) The Centre for Reproductive and Genetic…
Preexisting Previous VTE Single Estrogen or pregnancy related Thrombophilia related Unprovoked Related to temporary risk factor Recurrent events Thrombophilia Heritable Antithrombin deficiency Protein C deficiency Protein S deficiency Factor V…
Time between drug administration and neuraxial puncture, catheter manipulation or withdrawal Time between neuraxial puncture, catheter manipulation or withdrawal and drug administration Laboratory tests ESA ASRA ESA ASRA Unfractionated…
Condition Fetal Alloimmune Congenital infection (e.g. CMV, toxoplasma, rubella, HIV) Aneuploidy (e.g. trisomies 13, 18, 21) Autoimmune (e.g. ITP, SLE) Severe rhesus hemolytic disease Inherited (e.g. Wiskott-Aldrich syndrome) Early-onset…
17. Rahimy MC, Gangbo A, Adjou R, Deguenon C, Goussanou S, Alihonou E. Effect of active prenatal management on pregnancy outcome in sickle cell disease in an African setting. Blood….
Primary features Pathophysiology Complications Treatment DIC Abnormal coagulation (increased PT, APTT, reduced fibrinogen and platelets) Underlying precipitant, e.g. placental abruption, sepsis Excessive bleeding or thrombosis Treat the underlying cause…
Author and year HPA-1a (%) HPA-1b (%) HPA-3a (%) HPA-5a (%) HPA-5b (%) HPA-15 (%) HPA-1a & HPA-5b (%) Other (%) Reznikoff-Etievant (1988) [23] 90 Mueller-Eckhardt et al. (1989) [24]…
Variable GT ITP Gestational age at diagnosis (weeks) 32.8 ± 7.6 20.1 ± 11.1 Gestational age when platelet count counts at nadir (weeks) 35.7 ± 5.5 27.0 ± 11.2 Platelet count at diagnosis (×109/L) 71.3 ± 19.2 40.0 ± 25.5 Platelet count…
Maternal age over 40 years Multiparity Previous Cesarean section Uterine scarring (previous myomectomy, uterine curettage) Previous spontaneous or induced miscarriage Cigarette smoking and use of drugs such as cocaine Multiple…
Severe phenotype platelet function disorders Severe Glanzmann thrombasthenia Severe Bernard-Soulier syndrome Non-severe phenotype disorders Defects in platelet aggregation or adhesion Rare Glanzmann thrombasthenia variants (type II) Rare Bernard-Soulier syndrome variants…
