Targeted therapies and immune checkpoint inhibitors have significantly improved outcomes in a sizable fraction of patients with metastatic non-small cell lung cancer. Nevertheless, a majority of patients with lung cancer…
Daniel Morgensztern, MD, Editor Roy S. Herbst, MD, PhD, Editor Lung cancer is the leading cause of cancer mortality worldwide. Despite the poor outcomes, particularly for patients with advanced stage,…
and Francesco J. DeMayo2 (1) Translational Biology and Molecular Medicine Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA (2) Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030,…
Cattle type No. studies Specific days of EEM Incidence of EEM Mean (range) Reference Beef heifers 2 2–16 21.8 % (4.5–43.7 %) a Dairy heifers 1 2–6 28.9 % b…
Fig. 11.1 Schematic representation of the most important hormonal mechanisms regulating canine luteal function (Modified from Kowalewski et al. (2014b)). A detailed explanation is provided in the text. COX2/PTGS2 cyclooxygenase…
Fig. 7.1 Early pregnancy events in sheep. This schematic summarizes the relative changes in embryo/blastocyst/conceptus development after fertilization in relation to position in the female reproductive tract and circulating levels…
Fig. 8.1 The luteostatic “endocrine–exocrine” model for maternal recognition of pregnancy in the pig. In cyclic gilts, the loss of PGR in the uterine epithelia by day 10 of the…
Fig. 4.1 Structural representations of TMs. (a) MUC1, MUC4, MUC16 (not drawn to scale). Abbreviations: VNTR variable number of tandem repeats, SEA sea urchin sperm protein–enterokinase–agrin, TMD transmembrane domain, CT…
Fig. 6.1 The effect of elevated progesterone on conceptus elongation. Transient elevation of peripheral progesterone concentrations by exogenous administration results in the acceleration of conceptus development. Photographs illustrate elongating bovine…
Fig. 12.1 Photoperiodic and lactational control of diapause in the mink (LHS) and tammar (RHS). In the tammar, the sucking stimulus upregulates prolactin, inhibiting the corpus luteum, initiating and maintaining…
