Abstract A variety of systemic illnesses including acute and chronic infections, neoplastic diseases, connective tissue disorders, and storage diseases are associated with hematologic manifestations. Keywords Systemic illness, hematology, iron deficiency,…
Abstract Over the past several years, molecular diagnostic testing in patients with hematologic and oncologic disorders has become increasingly sophisticated and prevalent. While in the past focused genetic tests were…
Chapter Outline TECHNICAL CONSIDERATIONS Conventional Radiography Ultrasound Computed Tomography Magnetic Resonance Imaging Nuclear Medicine STAGING CONSIDERATIONS CENTRAL NERVOUS SYSTEM TUMORS Supratentorial Tumors Midline Supratentorial Tumors Infratentorial Tumors PULMONARY AND INTRATHORACIC…
Chapter Outline EPIDEMIOLOGY NEURODEVELOPMENT Neural Tube Development of Brain Structures Cancer Stem Cells Genetic and Signaling Pathways Implicated in Development and in Pediatric Tumors CONCEPTUAL ORGANIZATION OF PEDIATRIC BRAIN TUMORS…
Chapter Outline EPIDEMIOLOGY PRESENTATION AND EVALUATION STAGING AND GRADING TREATMENT Local Control Chemotherapy GENERAL BIOLOGIC FEATURES ADIPOCYTIC TUMORS FIBROBLASTIC AND MYOFIBROBLASTIC TUMORS Desmoid Tumor Infantile Myofibroma/Myofibromatosis and Hemangiopericytoma Infantile Fibrosarcoma…
Chapter Outline CYTOGENETIC AND MOLECULAR METHODOLOGIES Karyotyping Molecular Cytogenetics Polymerase Chain Reaction–Based Molecular Assays Array Comparative Genomic Hybridization and Single Nucleotide Polymorphism Profiling Assays Next-Generation Sequencing and Other Techniques GENOMIC…
Chapter Outline DEVELOPMENT OF THE GERMLINE Specification of Primordial Germ Cells Primordial Germ Cell Migration Erasure of Imprinting Gonadogenesis HISTOPATHOLOGY OF GERM CELL TUMORS Overview of Testicular Germ Cell Tumors…
Carlo Brugnara APPENDIX 1 Hematologic Values * in Normal Fetuses at Different Gestational Ages Week of Gestation Hemoglobin (g/dL) RBCs (×10 6 /mL) Hematocrit (%) Mean Corpuscular Volume (fL) Total WBCs…
Chapter Outline OROPHARYNGEAL CANCER NASOPHARYNGEAL CARCINOMA Epidemiology Presentation Staging and Evaluation Treatment THYROID CARCINOMA Epidemiology Pathology and Molecular Pathology Clinical Presentation and Staging Treatment and Outcome BREAST TUMORS PULMONARY TUMORS…
Chapter Outline ANTERIOR MEDIASTINAL MASSES Definition Clinical Presentation Evaluation and Imaging Treatment Conclusions SPINAL CORD COMPRESSION Clinical Presentation Evaluation and Imaging Treatment Late Effects HYPERLEUKOCYTOSIS AND LEUKOSTASIS Definition Pathogenesis Clinical…
