Red cell disorders
2Red cell disorders: anaemia, jaundice, polycythaemia and cyanosis Neonatal anaemia Definition and clinical significance of neonatal anaemia Anaemia is generally defined as a haemoglobin concentration or haematocrit at least two…
2Red cell disorders: anaemia, jaundice, polycythaemia and cyanosis Neonatal anaemia Definition and clinical significance of neonatal anaemia Anaemia is generally defined as a haemoglobin concentration or haematocrit at least two…
3Neonatal infection and leucocyte disorders Leucocyte abnormalities in neonatal systemic disease Increases in leucocyte numbers Increases in leucocyte numbers secondary to systemic disease are very common in neonates, particularly in…
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4Disorders of platelets and coagulation, thrombosis and blood transfusion Thrombocytopenia overview Thrombocytopenia is the commonest haematological abnormality in neonates, particularly among sick and/or very low birthweight neonates (reviewed in references…
“There are about 25 trillion red blood cells packed inside a single human body—line them side by side and they will circle the earth 15 times. This astoundingly large surface…
Viral Infections Certain viral infections can cause cytopathic changes in blood cells or changes in the maturation of blood cells. The nuclear or cytoplasmic inclusions of some viruses, particularly the…
In healthy adults and older children, the majority of circulating lymphocytes in the blood are T cells (approximately 70% of lymphocytes) with fewer B cells (25%) and natural killer (NK)…
Introduction Non-Hodgkin B-cell lymphomas are the seventh most common malignant neoplasm and account for approximately 4% of all cancers, according to the American Cancer Society, with approximately 77,000 cases anticipated…
Blood Collection In the United States, 14.2 million red blood cells and whole blood donations and approximately 2.4 million apheresis and whole blood–derived platelets were collected in 2013. Although whole…
T-Cell and Natural Killer–Cell Neoplasms With Primarily Leukemic Involvement T-Cell Prolymphocytic Leukemia Overview and Incidence T-cell prolymphocytic leukemia (T-PLL) is an aggressive, mature T-cell malignancy affecting predominantly older adults and…