Radionuclide Imaging of Head and Neck Paragangliomas
Fig. 13.1 Jugular PGL. Co-registered axial planes in MR TOF (time of flight) without gadolinium, CT (bone kernel), and MR TOF—CT rigid fusion with PGLs drawn in orange. 1 Jugular…
ENDOCRINOLOGY
Principles and Application of Molecular Imaging for Personalized Medicine and Guiding Interventions in Neuroendocrine Tumors
Fig. 10.1 Contrasting strengths and weaknesses of both anatomic and molecular imaging. The fusion of both modalities with hybrid PET/CT or PET/MRI enables the evaluation of function and anatomy contemporaneously…
Radionuclide Imaging of Chromaffin Cell Tumors
First syndromic manifestation Context at PPGL presentation (in index cases) PHEO at presentation Additional extra-adrenal PGL Predominant secretion PPGL-associated malignancy risk MEN2 MTC Adult Possible phenotypic features of MEN2…
Radionuclide Imaging of Pheochromocytoma and Paraganglioma in the Era of Multi-omics
Fig. 12.1 1H-NMR spectra of PPGLs. One-dimensional 500 MHz 1H-NMR spectra of PPGL tumor tissues at pH 2.50. Upper panel, sporadic tumor showing normal tumor metabolites like lactic acid, acetic…
Radionuclide Imaging of Medullary Thyroid Carcinoma
PET tracer Pooled detection rate for PET/CT Correlation between detection rate and serum calcitonin values Prognostic value Tolerance Radiation dose Radionuclide production Comparative costs Comparative availability Theranostic value FDG 59…
Nanoparticles for Radionuclide Imaging and Therapy: Principles
and Philippe Barthélémy1, 3 (1) Université de Bordeaux, Bordeaux, F-33076, France (2) CNRS, INCIA, UMR 5287, F-33400 Talence, France (3) INSERM U1212, UMR CNRS 5320, Bordeaux, F-33076, France Philippe Barthélémy Email:…
Radionuclide Imaging of Pulmonary and Thymic Neuroendocrine Tumors
Variable Typical carcinoid Atypical carcinoid Large cell NEC Small cell NEC Mitoses per 2 mm2 (10HPF) <2 2–10 ≥10 ≥10 Necrosis Absent Often punctate Often, large zones Frequent, large zones…
Molecular Genetics of MEN2-Related Neuroendocrine Tumours
Subtype % of total cases MTC (%) Pheo (%) HPT (%) Associated diseases MEN2A 91 98 Classical 46 100 50 25 Hirschsprung’s disease 5 100 20 Hirschsprung’s disease Cutaneous lichen…
Current and Future Radiopharmaceuticals in Neuroendocrine Tumor Imaging
Single Photon Emission Computed Tomography (SPECT) Radionuclide T 1/2 (h) Decay mode (%) E γ (keV) (%) Production mode 99mTc 6.02 IT (100) γ 141 (91) 99Mo/99mTc generator 111In 67.9…
Classification of Neuroendocrine Neoplasms
Fig. 1.1 Types of neuroendocrine neoplasms according to structure, system or organ of insurgence. LCNEC large cell neuroendocrine carcinoma, SCLC small cell lung carcinoma, GEP gastroenteropancreatic tract. World Health Organization…
