Triggers Causing Type 1 Diabetes
Fig. 2.1 Detailed genetic composition on human MHC (HLA) including type 1 diabetes risk Fig. 2.2 Communication and interaction pathways between an APC and T-cell. APC presents a processed antigen peptide via…
ENDOCRINOLOGY
Introduction to Diabetes and Type 1 Diabetes
Classification of diabetes Type 1 diabetes (T1D) Type 2 diabetes (T2D) Gestational diabetes Synonym IDDM, juvenile-onset diabetes NIDDM, adult-onset diabetes GDM Epidemiology 5–10 % of total cases 90–95 % of total cases…
Predictors and Pathogenesis of Type 1 Diabetes
Fig. 3.1 Model showing the progress of disease and potential stages of predictability and prevention of T1D relating it to the loss of β-cell mass and time. Modified from Eisenbarth (1986)…
Balance, Obesity and Type-2 Diabetes
Energy Balance Whether the net energy balance of an adult animal is positive or negative will depend upon energy intake versus energy expenditure as illustrated below (in growing animals another…
Manipulation of Mouse Metabolism.
In a typical experiment, animals of different genotypes or in different experimental conditions are challenged with one or more experimental diets, and their biological responses under these diets are compared…
of Overeating
Figure 1 Decreased activation in the caudate in response to milkshake receipt (contrasted with tasteless receipt) by weight change group over a 6-month period. Those that gained weight (solid line)…
Models of Obesity (DIO) in Rodents
Materials Adult male inbred mice, e.g., C57Bl6 (see Critical Parameters for considerations of age and group size) 60% Kcal fat, purified diet (Research Diets Inc., Harlan Teklad, Dyets Inc., Bio-Serv,…
