Chapter 1 – A Historical Review
Abstract Ancient concepts of the blood were described by Hippocrates and Galen 2000 years ago in their doctrine of “humors.” It was believed that the body was made up of…
Chapter 12 – Systemic Mastocytosis
Abstract Mastocytosis is a diverse group of rare diseases due to a clonal proliferation of neoplastic mast cells that can involve a wide variety of organ systems. The two main…
Chapter 15 – Mature Lymphoid Neoplasms
Abstract The classification of mature neoplasms has evolved over the years, with the current WHO classification based largely on the genetics and cellular origin of lymphoid neoplasms [1]. Clinical behaviour…
Chapter 19 – Immunohistochemistry and Flow Cytometry in Bone Marrow Haematopathology
Abstract Immunophenotyping is an important part of the integrated haematopathologic diagnostics of bone marrow (BM) samples. Integrated diagnosis should include clinical information, peripheral blood (PB) and BM smear cytology, flow…
Chapter 18 – Bone Marrow Changes Following Therapy and Immunosuppression
Abstract Bone marrow (BM) trephine biopsy (BMB) is a frequent and routine diagnostic investigation, as nicely described in the previous chapters, and is also widely used for follow-up of haematological…
Chapter 20 – Molecular Diagnostics in Bone Marrow Haematopathology
Abstract Molecular diagnostics, i.e. the detection and analysis of disease-related changes of DNA or RNA, is becoming ever more important for the diagnosis of bone marrow (BM) neoplasms. In modern…
Chapter 16 – Plasma Cell Neoplasia
Abstract Plasma cell neoplasms are derived from mature, IG heavy chain class-switched terminally differentiated B-cells, which usually secrete a monoclonal immunoglobulin or M-protein and consist of a homogeneous population of…
Chapter 17 – Metastatic Lesions
Abstract The bone marrow (BM) is a frequent site of haematogenous spread for all types of cancer. Metastatic spread of disseminated tumour cells (DTCs) to the BM is detected in…
Chapter 14 – Precursor Lymphoid Neoplasms
Abstract Neoplasms arising from precursor lymphoid cells committed to the B-cell or T-cell lineage can present primarily in the bone marrow (BM), blood (i.e. leukaemic presentation) or at extramedullary tissue…
Chapter 13 – Myeloid and Lymphoid Neoplasms Associated with Eosinophilia
Abstract Myeloid and lymphoid neoplasms with eosinophilia (MLNE) and rearrangements of PDGFRA, PDGFRB and FGFR1 were recognized as a standalone category in the 2008 WHO classification. PCM1-JAK2 was added to…
