Chapter 5 – Hyperplasia

Jan 4, 2021 by in HEMATOLOGY Comments Off on Chapter 5 – Hyperplasia

Abstract Bone marrow (BM) hyperplasia, a non-neoplastic expansion of one or more of the haematopoietic cell lineages due to an increased number of cells, can manifest in a range of…

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Chapter 11 – Myelodysplastic/Myeloproliferative Neoplasms

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Abstract The myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are clonal myeloid neoplasms characterized at the time of their initial presentation by the simultaneous presence of myelodysplastic and myeloproliferative features, which prevent them from…

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Chapter 9 – Acute Myeloid Leukaemia

Jan 4, 2021 by in HEMATOLOGY Comments Off on Chapter 9 – Acute Myeloid Leukaemia

Abstract Acute myeloid leukaemia (AML) is a highly complex and heterogeneous disease. Proper classification according to the 2016 World Health Organization (WHO) classification requires a systematic approach and integration of…

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Chapter 8 – Myelodysplastic Syndromes

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Abstract Myelodysplastic syndromes (MDS) comprise a heterogeneous group of myeloid neoplasms defined by peripheral cytopaenia, morphologic dysplasia in one or more haematopoietic lineages, and genetic instability with risk of transformation…

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Chapter 10 – Myeloproliferative Neoplasms

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Abstract The ‘classical’ Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), essential thrombocythaemia (ET), primary myelofibrosis (PMF) and polycythaemia vera (PV), are characterized by clonal myeloproliferation with effective maturation causing accumulation of terminally…

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Chapter 4 – Aplasia

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Abstract Aplasia is a pathologic term that is broadly defined as the absence or near-absence of one or more haematopoietic lineages in the bone marrow (BM). Clinically, BM aplasia affecting…

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Chapter 1 – The Bone Marrow Biopsy

Jan 4, 2021 by in HEMATOLOGY Comments Off on Chapter 1 – The Bone Marrow Biopsy

Abstract Trepanning of the bone is one of the oldest known procedures carried out by man and the use of the modern trephine biopsy has a venerable history. Parapia has…

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Chapter 2 – The Normal Bone Marrow

Jan 4, 2021 by in HEMATOLOGY Comments Off on Chapter 2 – The Normal Bone Marrow

Abstract Knowledge and understanding of the appearance of normal bone marrow (BM) and therefore normal haematopoiesis is essential for both general pathologists and specialist haematopathologists. It is only once normal…

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