Myeloproliferative Neoplasms Olga Pozdnyakova, MD, PhD Attilio Orazi, MD Myeloproliferative neoplasms (MPNs) are a group of clonal disorders of the hematopoietic stem cells that share similar features, such as hypercellular…
Acute Leukemias Julia T. Geyer, MD Sangmin Lee, MD Acute leukemias are hematologic malignancies characterized by increased numbers of myeloid or lymphoid blasts. The term “acute,” historically referring to a…
Myelodysplastic Syndromes Olga Pozdnyakova, MD, PhD Robert P. Hasserjian, MD The myelodysplastic syndromes (MDSs) are a heterogeneous group of disorders caused by a clonal expansion of hematopoietic stem cells in…
Benign Diseases of Leukocytes, Spleen, and Immunoglobulins Linlin Wang, MD, PhD Sonam Prakash, MBBS Benign disorders of white blood cells (WBC) can result in either quantitative or qualitative changes in…
Hemostasis and Platelet Disorders Marcia Paddock, MD, PhD John V. Mitsios, PhD Maria T. DeSancho, MD, MSc HEMOSTASIS AND ITS ROLE IN DISEASE Hemostasis Hemostasis is the process by which…
Techniques for Assessing Blood Disorders: Flow Cytometry, Multiplex Immunohistochemistry, Karyotyping, FISH, and Molecular Approaches Scott A. Ely, MD, MPH New techniques, platforms, and companies spring into view on a regular…
Approach to the Microscopic Evaluation of Blood and Bone Marrow Kseniya Petrova-Drus, MD, PhD Babette B. Weksler, MD EXAMINATION OF THE PERIPHERAL BLOOD Slide Preparation and Staining A hematologic evaluation…
Small Cell Lesions Small cell carcinomas and lymphomas constitute a common source of diagnostic error, often misclassified as anaplastic carcinomas [1, 2, 3, 4] (Figs. 13.1, 13.2, 13.3, e-Figs. 13.1,…
Squamoid, Spindle, and Giant Cell Lesions UNDIFFERENTIATED (ANAPLASTIC) CARCINOMA Anaplastic or undifferentiated carcinoma historically accounted for 5% to 10% of all primary malignant tumors of the thyroid [1], but in…
