Keywords bortezomib, chemotherapy, dexrazoxane, fertility preservation, in vivo animal models, mice, non-human primates, ovary, ovarian toxicity, ovoprotectant 5.1 Introduction The success of cancer treatment creates a growing population of…
Keywords anti-Müllerian hormone, antral follicle count, chemotherapy, infertility, ovarian reserve, premature ovarian insufficiency 3.1 Introduction Assessment of ovarian toxicity in the clinical setting is important in determining the effects…
Keywords amenorrhoea, BRCA genes, chemotherapy, DNA double-strand breaks, ovarian damage 4.1 Introduction Chemotherapy has considerably improved survival of many cancer types; however, a patient’s quality of life is influenced…
Keywords chemotherapy, granulosa cells, oocytes, primary ovarian insufficiency, radiotherapy 2.1 Introduction More than 75% of children treated for malignant disease will be alive 10 years following initial diagnosis in…
Keywords endocrine system, follicle, follicle activation, follicle death, folliculogenesis, ovarian hormones, ovarian reserve, ovary 1.1 Overview of Ovarian Function The ovary serves two roles – the production of hormones…
Abstract Misdiagnosis or delay in diagnosis of breast cancer is one of the most common causes of malpractice litigation. Many different issues account for the number of legal cases related…
Abstract Attention to issues related to breast cancer survivorship is important to optimize oncologic outcomes and quality of life. Patients, cancer care providers, and primary care providers must work collaboratively…
Abstract The diagnosis of breast cancer generates significant distress in the lives of patients and their families because cancer is often considered synonymous with death, pain, and suffering. The first…
Abstract It has been demonstrated that as a result of breast cancer and its treatment, survivors of the disease experience a high prevalence of functional impairments. Survivors may experience short-term,…
Abstract Many women with breast cancer are menopausal at the time of their cancer diagnosis, and a significant number will enter menopause during treatment. Achievement of adequate control of menopausal…
