The canonical endocytic pathway progresses along an increasing lumen-acidic gradient from early endosomes retrogradely trafficked from the plasma membrane, to multivesicular bodies or late endosomes, and finally to perinuclear-localized lysosomes….
Related posts: 18: Neuronal Ceroid Lipofuscinoses 17: Lysosomal Membrane Defects 8: The Gangliosidoses 5: Classification of Lysosomal Storage Diseases 24: The Patient Perspective on Rare Diseases 12: The Mucopolysaccharidoses
Related posts: 18: Neuronal Ceroid Lipofuscinoses 17: Lysosomal Membrane Defects 8: The Gangliosidoses 5: Classification of Lysosomal Storage Diseases 24: The Patient Perspective on Rare Diseases 12: The Mucopolysaccharidoses
Age Changes 1. Impairment of smell and taste can further reduce poor appetite. 2. Older people cannot open their mouths as wide and chew with less power than younger people….
Age Changes 1. Loss of cardiac myocytes secondary to apoptosis, with compensatory hypertrophy of remaining cells. 2. Accumulation of intracellular lipofuscin and extracellular amyloid. 3. Increased intercellular collagen, leading to…
Age Changes Brain weight decreases by 20% from its young adult weight by the age of 90. Selective neuronal loss of 5–50%, and cells tend to shrink. Fifteen to twenty…
Bones Age Changes Bone structure changes throughout life owing to ongoing bone resorption by osteoclasts and bone growth by osteoblasts. With increasing age, the balance is lost, leading to a…
Eyes Age-Related Changes 1. Eyes appear sunken due to loss of periorbital fat. 2. Arcus senilis (deposition of calcium and cholesterol salts in a ring at the edge of the…
Age Changes and Clinical Examination 1. A full neurological examination can be an ordeal for both a frail elderly patient and their doctor. Patience and understanding are required by both…
Importance Anyone can have a stroke, including babies and children, but the vast majority (90%) of strokes affect people aged over 55. Each year over 150,000 people in the UK…
