Exchange transfusion and haemapheresis
where Hn is the venous haematocrit of the recipient’s own red cells after n operations. The total PCV after n operations is calculated by: The first term represents…
Blood grouping techniques
The most reliable results for the detection and identification of red cell antibodies are obtained by using a combination of tests. The particular combination of tests adopted in specialist blood…
Infectious agents transmitted by transfusion
The need to develop sensitive and specific assays amenable to mass screening and automation has become apparent. However test manufacturers are increasingly reluctant to invest resources for screening if the…
Haemolytic transfusion reactions
Mrs H was a regular plasmapheresis donor. On the day in question, after she had given blood and before her red cells were returned to her, she was asked to…
Some unfavourable effects of transfusion
The high fever that regularly follows transfusion of some multiparous women and patients who have received many transfusions is often associated with serum leucocyte antibodies; mild febrile reactions, observed after…
Plasma fractionation and fractionation products
Albumin was the only plasma concentrate used in World War II. However the other plasma fractions were retained and analyzed later. An entire industry which now involves tons of plasma…
12: The Mucopolysaccharidoses
Case history A 6-year-old boy was taken to the doctor to review the skeletal X-rays, requested on the previous consultation. The mother reported that pregnancy and birth were uneventful. The…
21: Central Nervous System Aspects, Neurodegeneration and the Blood–Brain Barrier
2 Department of Paediatrics, University of Padova, Padova, Italy Introduction Of the 50 or more described lysosomal storage diseases (LSDs) the majority are neuronopathic and associated with profound neurodegeneration. The…
