Immunology of red cells
According to RE Rosenfield (1977, supplemented by personal communication), L Buchbinder, a PhD student of Karl Landsteiner, had discovered Rh polymorphism at some time in the 1930s, but Landsteiner had…
The transfusion of red cells
The Effect of Splenectomy Following splenectomy, red cell survival has been found to be normal in humans and rabbits (Miescher 1956a; McFadzean et al. 1958), although slightly prolonged in rats…
Haemolytic disease of the fetus and the newborn
), Woodrow and Donohoe (1968); 2 (), E Borst-Eilers (personal communication); 3 (•), Poulain and Huchet (1971). In Figure 12.1, the magnitude of TPH on a logarithmic scale is plotted…
The Rh blood group system (including LW and RHAG)
Although numbers up to 56 are included in Table 5.1, some are omitted: 13–16, because they were given to RhA, etc., no longer regarded as distinct antigens; and 25, because…
Alternatives to allogeneic transfusion
Currently, six parenteral iron preparations are available, although carboxymaltose (Injectafer) is not licensed in the US (Table 18.1). No randomized trials have compared the safety and efficacy of these agents…
The transfusion of platelets, leucocytes, haematopoietic progenitor cells and plasma components
The blood was collected by gravity in uncoated glass bottles containing acid citrate dextrose, solution A (NIH and USP) as an anti-coagulant. The bottles were then stored at 5°C for…
ABO, H, LE, P1PK, GLOB, I and FORS blood group systems
The regular presence of anti-A and anti-B is made use of in the routine determination of ABO blood groups; in addition to testing red cells for A and B antigens,…
Blood donors and the withdrawal of blood
There is a wide variation in the recommended minimum interval between donations. For example in the US, in line with World Health Organization (WHO) recommendations, the interval can be as…
Transfusion of blood, blood components and plasma alternatives in oligaemia
If normal values are substituted in the equations above, a healthy adult male of 70 kg body weight will have an O2 delivery of about 1000 ml/min. His basal O2…
Red cell antibodies against self-antigens, bound antigens and induced antigens
The titre of normal autoagglutinins at 0–2°C does not usually exceed 64 using a tube technique with a 2% cell suspension and reading the results microscopically (Dacie 1962, p. 460),…
