Chapter 4 Strategic Use of Antiretroviral Therapy Michael S. Saag, MD Over the last decade, highly active antiretroviral therapy (HAART) has revolutionized the care of human immunodeficiency virus (HIV) infected…
Chapter 21 Atazanavir Graeme Moyle, MD Atazanavir is a relatively new protease inhibitor (PI) that is dosed once daily with or without ritonavir boosting. Since its approval atazanavir has been…
Chapter 66 Ophthalmologic Disease Douglas A. Jabs, MD, MBA, Jennifer E. Thorne, MD, PhD Ocular manifestations are common in patients with AIDS, and in the era before highly active antiretroviral…
Chapter 63 AIDS Psychiatry Alex Thompson, MD, MBA, Benjamin C. Silverman, BA, Andrew Angelino, MD, Glenn J. Treisman, MD, PhD INTRODUCTION HIV infection is spread through intimate contact, which involves…
Chapter 25 Tipranavir Véronique Joly, MD, Patrick Yeni, MD INTRODUCTION The availability of potent antiretroviral drugs, including protease inhibitors (PI), and their use in combination regimens–highly active antiretroviral therapy (HAART)–has…
Chapter 70 HIV-Related Renal Disease Jonathan A. Winston, MD, Paul E. Klotman, MD Diseases of the kidney are generally classified into one of two broad clinical syndromes, acute renal failure…
Chapter 75 Bone Disorders Val Amorosa, MD, Pablo Tebas, MD OSTEOPOROSIS Introduction Osteoporosis is a disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced…
Chapter 44 Histoplasmosis Lawrence J. Wheat, MD INTRODUCTION Histoplasmosis is a serious opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS) in endemic regions of America, Africa, and Asia, although…
Chapter 24 Inhibiting the Entry of R5 and X4 HIV-1 Phenotypic Variants Shawn E. Kuhmann, PhD, Roy M. Gulick, MD, MPH, John P. Moore, PhD Compounds that prevent HIV-1 from…
Chapter 74 Lactic Acidosis and Other Mitochondrial Disorders Associated with HIV Therapy David Nolan, MD, Simon Mallal, MD INTRODUCTION Nucleoside analog reverse transcriptase inhibitors (NRTI) were the first class of…
