Study Year Study population Method Main Result 1-(Snell et al. 2008) 2008 Familial breast cancer without BRCA1or BRCA2 mutations MethyLight, MS-HRM (Methylation specific high resolution melting) Hypermethylation of BRCA1 in tumors,…
Species Chromosomal location Gene symbol Size Other symbols Human 3p24.2 RARB 423 kb HAP, RRB2, NR1B2, MCOPS12 Mouse 14 A1-A3; 14 7.08 cM Rarb 164 kb Hap, Nr1b2, RARbeta2, A830025K23…
Fig. 4.1 Gross specimen showing a white pearly irregular tumor with pale yellow gritty areas likely corresponding to comedo necrosis Classic histologic features of DCIS include cohesive, clonal-appearing epithelial cells…
Fig. 3.1 Secretory calcifications present as large rod-like calcifications and are associated with ductal ectasia Fig. 3.2 Milk of calcium is associated with fibrocystic changes. a Cranial caudal view demonstrates…
Variable BRCA1 BRCA2 Surrounding invasive tumor < Sporadic controls = Sporadic controls Presence in prophylactic mastectomy specimens Increased in women more than 40 years of age Increased in women over 40 years…
Fig. 1.1 Age-adjusted Surveillance, Epidemiology, and End Results (SEER) incidence rates by age at diagnosis/death; breast (in situ), female, all races, female 1975–2011 (SEER 9; Cancer sites include invasive cases…
RCT RR mortality RR node positive HIP 0.78 0.85 Malmö 0.78 0.83 Two County 0.68 0.73 Edinburgh 0.78 0.81 Stockholm 0.90 0.82 NBSS1 0.97 1.20 NBSS2 1.02 1.09 Gothenburg 0.79…
Fig. 17.1 Distribution of racial/ethnic subsets in the general population of women in the USA compared to the distribution of racial-ethnic subsets among women with ductal carcinoma in situ in…
© Springer Science+Business Media New York 2015Lisa A. Newman and Jessica M. Bensenhaver (eds.)Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer10.1007/978-1-4939-2035-8_16 16. Introduction, Evolution, and Application of the Van Nuys Prognostic Index in DCIS Aeisha…
Fig. 14.1 Baseline and follow-up mammograms in a 51-year-old woman with initial diagnosis of DCIS, treated with breast-conserving surgery and adjuvant radiation. Left breast mammogram at initial diagnosis and at…
