Potential linkers Source Functions in inflammation Functions in angiogenesis References TNF-α Macrophages Tumor cells Augments E-selectin and VCAM-1 on ECs to promote leukocyte adhesion and inflammation Induces COX-2 Induces IL-8…
33. Toh B, Wang X, Keeble J, Sim WJ, Khoo K, Wong WC, et al. (2011) Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating…
© Springer Science+Business Media New York 2015Steven M. Dubinett (ed.)Inflammation and Lung Cancer10.1007/978-1-4939-2724-1_7 7. Inflammation and Lung Cancer: Addressing Inflammation with Immunotherapy Sherven Sharma1 , Siwen Hu-Lieskovan2 , Steven M. Dubinett3 and Jay Moon Lee4 (1) Division of Pulmonary and…
Fig. 3.1 Inflammation in lung cancer development. Carcinogens in tobacco smoke induce inflammatory damage directly on normal epithelium. Additionally, exposure to tobacco smoke leads to induction and recruitment of proinflammatory…
Target antigens Antibody medicines Tumor types Mechanisms of tumor killing Hematopoietic cell differentiation antigens CD20 Rituximab Non-Hodgkin’s lymphoma ADCC Tositumomab Non-Hodgkin’s lymphoma 131I Ibritumomab 90Y CD22 Inotuzumab Non-Hodgkin’s lymphoma Ozogamicin…
Fig. 15.1 Characteristic features of immature and mature dendritic cells (DCs) Generally, cancer antigens or the long peptides are engulfed by DCs, digested into helper and killer epitope peptides by…
Fig. 14.1 Strategy of Wilms’ tumor gene (WT1) product-derived peptide vaccination combined with bacillus Calmette-Guérin cell wall skeleton (BCG-CWS). Intradermally (i.d.) injected BCG-CWS binds to Toll-like receptor (TLR) 2 and 4…
Fig. 19.1 Search for transformation-associated cell surface molecules induced by activated oncogene introduction into murine fetal fibroblasts, rat WFB cells and mouse BALB3T3 cells Meanwhile, as shown in Fig. 19.2,…
Fig. 20.1 Mechanisms for the differential immune status among cancer patients. Balance of the anti-tumor T cell induction pathway and immunosuppressive pathway along with environmental factors may define the differences…
Fig. 3.1 M2 tumor-associated macrophages (TAMs) support tumor growth and progression. Circulating monocytes recruited by tumor-derived chemoattractants develop into TAMs in the tumor microenvironment. TAMs generally show an M2-like phenotype….
