Oncohema Key

Uncommon B-Cell Lymphom Jeremy S. Abramson, Jeffrey A. Barnes Multiple uncommon B-cell lymphomas each account for only a small percentage of non-Hodgkin lymphomas overall, but should be familiar to clinicians…

Non-Small Cell Lung Cancer Justin F. Gainor, Jeffrey A. Engelman INTRODUCTION EPIDEMIOLOGY Lung cancer is the leading cause of cancer-related mortality in the United States, with an estimated 160,000 deaths…

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Colon Cancer David P. Ryan EPIDEMIOLOGY STATISTICS In the United States, 102,480 new cases of colon cancer were expected in 2013 (men 50,090; women 52,390) (1), and 40,340 new cases…

Soft Tissue and Bone Sarcomas Edwin Choy, Sam S. Yoon, Francis J. Hornicek, Thomas F. DeLaney SOFT TISSUE SARCOMAS Soft tissue sarcomas (STS) are uncommon malignancies, arising in about 11,410…

Topoisomerase Inhibitors: Camptothecins, Anthracyclines, and Etoposide Bruce A. Chabner Topoisomerases carry out the important function of unwinding DNA by creating temporary breaks in DNA, promoting passage of single strands of…

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Breast Oncology: Clinical Presentation and Genetics Amy Comander, Tessa Cigler, Paula D. Ryan EPIDEMIOLOGY In the United States, breast cancer is the most commonly diagnosed cancer among women and is…

Antimetabolites: Nucleoside and Base Analogs Bruce A. Chabner ANALOGS OF DNA PRECURSORS; GENERAL CONSIDERATIONS The synthesis of new DNA is an essential step in the replication of normal and malignant…

Metastatic Breast Cancer Steven J. Isakoff INTRODUCTION Since 1990, the annual rate of breast cancer death has been decreasing by approximately 2.2% per year (1). Historically, median survival of patients…