Genetics of Chronic Lymphocytic Leukemia Andrea Schnaiter, MD, Daniel Mertens, PhD, Stephan Stilgenbauer, MD *stephan.stilgenbauer@uniklinik-ulm.de, Department of Internal Medicine III, University of Ulm, Albert Einstein Allee 23, 89081 Ulm, Germany…
Chromosomal Structural Rearrangements: Detection and Elucidation of Mechanisms Using Cytogenomic Technologies Sarah T. South, PhD a,b,*sarah.south@aruplab.com, a Cytogenetics, Genomic Microarray, Genetic Processing at ARUP Laboratories, 500 Chipeta Way, Salt Lake…
Laboratory Aspects of Prenatal Microarray Analysis Allen N. Lamb, PhD a,b,*allen.n.lamb@aruplab.com, a Cytogenetics and Genomic Microarray Laboratory, ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA b…
Lymphoma Cytogenetics Bhavana J. Dave, PhD a,b,*bdave@unmc.edu, Marilu Nelson, MS, CG, MB (ASCP)CM b, Warren G. Sanger, PhD a,b a Departments of Pediatrics, Pathology/Microbiology, Munroe Meyer Institute for Genetics and…
Chronic Myeloid Leukemia: Current Perspectives Yanming Zhang, MD a,b,*yanming-zhang@northwestern.edu, Janet D. Rowley, MD c a Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry Building…
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Fig. 1 Overlap between Cushing’s syndrome and metabolic syndrome Although the example of Cushing’s syndrome makes a link between cortisol and obesity in the general population theoretically plausible, it represents…
Fig. 1 Main clinical manifestations after remission of Cushing’s syndrome This chapter addresses current information on the main long-term/persistent effects of prior Cushing’s disease/glucocorticoid exposure. Cardiovascular and Metabolic Comorbidities Hypercortisolism…
Target tissue Glucocorticoid hypersensitivity = Glucocorticoid excess Glucocorticoid resistance = Glucocorticoid deficiency Central nervous system Insomnia, anxiety, depression, defective cognition Fatigue, somnolence, malaise, defective cognition Liver + Gluconeogenesis, + lipogenesis…
Adrenocortical adenoma Micronodular disease Macronodular disease MAS PPNAD/iMAD/CNC BMAH A. Genetic alterations 1. cAMP/PKA signaling pathway – – MC2R a (missense) – GNAS a – GNAS a GNAS a…
