Hypermutated Colorectal Cancer and Neoantigen Load
Fig. 8.1 DNA mismatch errors commonly occur at unstable genomic regions with multisatellite repeats. The repair of such DNA mismatch errors is the function of the MMR system. This process…
Therapeutic Cancer Vaccines
Fig. 3.1 Cancer vaccination and induction of T cell activation Vaccine Platforms and Vectors Common Mechanisms of Action This section will discuss various therapeutic cancer vaccine constructs, including peptide, DNA,…
PD1 and PD-L1 Immune Checkpoint Inhibitors in Gastrointestinal Cancer
Phase Regimen Patient population Results I Pembrolizumab (anti-PD-1 antibody) Advanced solid tumours, including oesophageal cancer ORR: 30.4 % (29.4 % in squamous cell carcinoma vs. 40 % in adenocarcinoma); 12-month…
Let’s Talk About Stress
• A review of 165 studies found that stress-related psychosocial factors are associated with higher cancer incidence in initially healthy populations, poorer survival in patients diagnosed with cancer (330 studies),…
Bringing It All Together
Welcome and introduction to the clinic This could be a one-pager that welcomes the patient to the clinic, provides an explanation of the philosophy of the clinic and the modalities…
The Ultimate Consultation—An Overview
1. For the Ultimate Consultation you need the Ultimate Patient to obtain the Ultimate Result 2. The Ultimate Consultation focuses on Seven Key Health Strategies 3. The Ultimate Consultation requires…
The Power of Movement: Integrating Exercise
• A study of women with non-metastatic colorectal cancer (Nurses’ Health Study Cohort) found that higher levels of exercise after diagnosis was significantly associated with reduced cancer-specific death and overall…
Malignant Tumors of the Liver and Intrahepatic Bile Ducts
Fig. 7.2 Surgical resection of hepatobiliary tumors during the 30-year period in the EHBH 7.1.1.3 Pathogenesis and Mechanism Currently, it is suggested that HCC relates to the following pathogenic factors:…
