Fig. 5.1 Continuum of translational research (Khoury et al. 2010; Glasgow et al. 2012) T0 scientific discovery research, T1 translational research from discovery to candidate application, T2 translational research from…
Chromosomal translocations Genes Comments Involving RARAα t(15;17)(q21;q21) PML DNA binding, cell proliferation RARα Transcription factor t(11;17)(q23;q21) ZBTB16 (PLZF) Zn-finger transcription factor RARα Transcription factor t(5;17)(q32;q21) NPM1 RNA transport/processing RARα Transcription…
(1) Department of Patholog, University of Massachusetts Medical School, Baystate, Springfield, MA, USA (2) Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC,…
Fig. 1.1 Cancer incidence and mortality by site for both sexes (USA, 2015). The relative contributions of the major forms of cancer to overall cancer incidence and cancer-related mortality (both…
Fig. 40.1 Discovery of imatinib . Binding of imatinib occurs at the ATP-binding site as indicated by docking studies [28] and X-ray crystallography [29]. It has also been shown from…
Fig. 2.1 Chemical structures of DNA and RNA. The DNA within the eukaryotic nucleus is arranged in a double-stranded helix composed of two strands of opposing polarity. The helix is…
Fig. 13.1 Genetic heterogeneity of cancer cells. All cancer cells are derived from a common ancestor cell (black dot) that was subject to the pathogenic mutation (w). After an initial…
Fig. 35.1 MRI sequences of common primary brain tumors. (a) Sagittal T1-weighted and gadolinium-enhanced MR image showing a medulloblastoma in the posterior fossa (arrow) with compression of the pons and…
Fig. 3.1 Expression profiling schema. Above, schematic depiction of two-color hybridization on cDNA or oligonucleotide microarrays. RNA isolated from test and reference samples is labeled with two different fluors (here…
Fig. 22.1 Aldred Scott Warthin, M.D., Ph.D., (1866–1931) pioneer in hereditary cancer research. Fig. 22.2 Pedigree family G . This family was described in the first published systematic evaluation of…
