Oncohema Key

63.1 Insufficiency fracture The world population is aging with its many manifestations, not least in the sale of diapers. Recently in Japan, for the very first time ever, the sale…

63.1 Insufficiency fracture The world population is aging with its many manifestations, not least in the sale of diapers. Recently in Japan, for the very first time ever, the sale…

54.1 Introduction Since the kidney is essential for regulation of mineral metabolism, bone disease is an inevitable consequence of renal damage. Treatment is challenging due to the complex physiology and…

81.1 Introduction Analysis of the iliac crest bone biopsy provides information on cellular behavior and the material properties of bone matrix that cannot be obtained by any other technique. For…

Osteoporosis is characterized by low bone mineral density (BMD) and poor bone structure. Both increase bone fragility and are influenced by bone turnover. Bone turnover comprises formation of new bone…

78.1 Introduction Testosterone is the principal circulating androgen in men, secreted almost entirely by the testes. The effects of testosterone on bone in men are therefore best observed when they…

40.1 Introduction Fuller Albright speculated that removal of the stress and strain on the skeleton would result in bone loss . Of the total noninstitutionalized population in the United States…

48.1 Scope of the problem Although osteoporosis is primarily considered an issue for postmenopausal women and men over age 65 years, physicians are increasingly confronted with low bone mass or…

45.1 Introduction More than 75 years ago, osteoporosis associated with endogenous glucocorticoid excess was described by Cushing . More common is the increased fracture risk associated with exogenous glucocorticoids, a…

74.1 Introduction and history Bisphosphonates are analogs of naturally occurring compounds, pyrophosphates (P–O–P). P–O–P are byproducts of adenosine triphosphate (ATP) metabolism but have little or no biological activity in healthy…