Teriparatide and abaloparatide treatment for osteoporosis

Oct 27, 2020 by in ENDOCRINOLOGY Comments Off on Teriparatide and abaloparatide treatment for osteoporosis

76.1 Introduction Teriparatide (TPTD), the aminoterminal (1-34)parathyroid hormone (PTH) peptide, is a proremodeling anabolic agent. When administered by daily subcutaneous injection, it first stimulates bone formation (primarily modeling based) and…

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Impact of MGUS and myeloma on skeletal health

Oct 27, 2020 by in ENDOCRINOLOGY Comments Off on Impact of MGUS and myeloma on skeletal health

58.1 Introduction Multiple myeloma (MM) is an incurable plasma cell dyscrasia and the second most frequent hematologic malignancy, with an incidence of 5.85/100,000 adults in Western countries and a 5-year…

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Denosumab for the treatment of osteoporosis

Oct 27, 2020 by in ENDOCRINOLOGY Comments Off on Denosumab for the treatment of osteoporosis

Denosumab is a monoclonal antibody that binds receptor activator of nuclear factor kappa-β ligand (RANKL). Its development followed the discovery and description of the central role of the RANKL–RANK pathway…

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