Endocrine Function of the Gastrointestinal Tract

Jul 15, 2019 by in ENDOCRINOLOGY Comments Off on Endocrine Function of the Gastrointestinal Tract

Objectives 1. List the members of the three enteroendocrine hormone families: gastrin, secretin, and motilin. 2. Describe how autonomic innervation and gastric and duodenal hormones regulate gastric acid secretion and…

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Abbreviations and Symbols

Jul 15, 2019 by in ENDOCRINOLOGY Comments Off on Abbreviations and Symbols

αGSU alpha glycoprotein subunit β-hCG hormone-specific β-subunit of hCG β-TSH β-Thyroid-stimulating hormone 3β-HSD 3β-hydroxysteroid dehydrogenase 11β-HSD2 11β-hydroxysteroid dehydrogenase 17β-HSD 17β-hydroxysteroid dehydrogenase AA amino acid ABP androgen-binding protein ACE angiotensin-converting enzyme…

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The Thyroid Gland

Jul 15, 2019 by in ENDOCRINOLOGY Comments Off on The Thyroid Gland

Objectives 1. Explain the mechanisms of thyroid hormone synthesis. 2. Describe the regulation of thyroid function and the actions of thyroid hormones. 3. Compare and contrast the functions of thyroxine…

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Preclinical Approaches to the Protection of Ovarian Function

Jul 13, 2019 by in ONCOLOGY Comments Off on Preclinical Approaches to the Protection of Ovarian Function

Keywords apoptosis, chemotherapy, fertility, ovary, preservation, primordial follicles   9.1 Introduction Recent advances in our understanding of the mechanisms underlying the impact of cytotoxic drugs on the ovary have opened…

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Ovarian Tissue Cryopreservation for Fertility Preservation

Jul 13, 2019 by in ONCOLOGY Comments Off on Ovarian Tissue Cryopreservation for Fertility Preservation

Keywords autotransplantation, fertility preservation, malignant cell contamination, outcome, ovarian tissue cryopreservation   7.1 Overview The survival rate among the ~2% of women of reproductive age who have suffered from invasive…

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In Vitro Models of Ovarian Toxicity

Jul 13, 2019 by in ONCOLOGY Comments Off on In Vitro Models of Ovarian Toxicity

Keywords animal models, apoptosis, chemotherapy, culture, follicle, in vitro , ovary, primary effects   6.1 Introduction Investigating the precise effect of chemotherapy on female fertility is a key research aspect…

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Current Clinical Approaches to Protecting the Ovary: GnRH Analogues

Jul 13, 2019 by in ONCOLOGY Comments Off on Current Clinical Approaches to Protecting the Ovary: GnRH Analogues

Keywords chemotherapy, fertility preservation, gonadotoxicity, gonadotropin-releasing hormone (GnRH) agonist, ovarian protection   8.1 Introduction Cancer is not uncommon and no longer considered as an incurable disease among reproductive-age women. Indeed,…

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In Vivo Models of Ovarian Toxicity

Jul 13, 2019 by in ONCOLOGY Comments Off on In Vivo Models of Ovarian Toxicity

Keywords bortezomib, chemotherapy, dexrazoxane, fertility preservation, in vivo animal models, mice, non-human primates, ovary, ovarian toxicity, ovoprotectant   5.1 Introduction The success of cancer treatment creates a growing population of…

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Clinical Assessment of Ovarian Toxicity

Jul 13, 2019 by in ONCOLOGY Comments Off on Clinical Assessment of Ovarian Toxicity

Keywords anti-Müllerian hormone, antral follicle count, chemotherapy, infertility, ovarian reserve, premature ovarian insufficiency   3.1 Introduction Assessment of ovarian toxicity in the clinical setting is important in determining the effects…

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