Fig. 9.1 Immunohistochemical staining for ALK is typically diffuse with granular cytoplasmic staining (ALK D5F3, 200×). Image courtesy of Dr. Natasha Rekhtman c-ros Oncogene 1 (ROS1) The prevalence of patients…
Fig. 8.1 (a) Fusion probe FISH assay negative for translocation (“split signal”). (b) Fusion probe FISH assay positive for translocation (“fusion signal”) Fig. 8.2 (a) Break-apart probe FISH assay negative…
Fig. 11.1 Molecular landscape of lung adenocarcinoma. Estimation of mutation prevalence is based on targeted next generation sequencing of lung adenocarcinomas performed at Brigham and Women’s Hospital and Dana–Farber Cancer…
Drug Drug specificity Cut-offs used in trialsa Unless stated, these represent % tumour cells stained: cell membrane staining PD-L1 immunohistochemistry primary antibody clone Complementary or companion diagnostic test Staining platform…
Inhibitor Study design Response rate Median PFS (months) Median OS (months) Reference Crizotinib Phase 1 57% Not reached n/a Kwak et al. [5] Crizotinib Phase 1 60.8% 9.7 Not reached…
Fig. 6.1 Tissue processing and tumor characteristics involved in specimen adequacy assessment. Tissue processing fixatives and decalcification methods that are suitable for molecular testing are designated with a green check,…
© Springer International Publishing AG 2018Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier and Eric H. Bernicker (eds.)Precision Molecular Pathology of Lung CancerMolecular Pathology Libraryhttps://doi.org/10.1007/978-3-319-62941-4_21…
© Springer International Publishing AG 2018Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier and Eric H. Bernicker (eds.)Precision Molecular Pathology of Lung CancerMolecular Pathology Libraryhttps://doi.org/10.1007/978-3-319-62941-4_19…
© Springer International Publishing AG 2018Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier and Eric H. Bernicker (eds.)Precision Molecular Pathology of Lung CancerMolecular Pathology Libraryhttps://doi.org/10.1007/978-3-319-62941-4_18…
Fig. 15.1 Uncommon carcinomas. (a) Sarcomatoid carcinoma , pleomorphic carcinoma type with large cell undifferentiated carcinoma (left) and spindle cell pattern on the right. (b) Sarcomatoid carcinoma, spindle cell type….
