Conditioning Regimens
Regimen Disease states treated Comments Cy + ATG + / – TBI Aplastic anemia TBI added for unrelated donors (URD) tBu–Cy AML, ALL, CLL, CML, NHL, MM, MDS The busulfan exposure target varies by disease…
Social Work: Evaluation and Support
Organization URL Transplant resources Be the match www.marrow.org Blood and marrow transplant information network (BMT Infonet) www.bmtinfonet.org BMT support online www.bmtsupport.org Explore BMT www.explorebmt.org National bone marrow transplant link…
Mantle Cell Lymphoma
Better prognosis Poorer prognosis MIPIa score (Geisler et al. 2010) Low Intermediate or high MIPI-bb score (Schaffel et al. 2010) Low Intermediate or high Posttreatment MRDc (Pott et al….
Cytogenetics
Fig. 2.1 Application of FISH in lymphoma diagnostics and research. (a) Scheme of the dual-color, break-apart probe for BCL6 translocations (www.abbottmolecular.com); Scheme of the dual-color, dual-fusion translocation probe for the…
CNS Lymphoma
Fig. 11.1 A rare case of primary CNS lymphoplasmacytic lymphoma demonstrating a perivascular lymphoid infiltrate (10×) composed of lymphoplasmacytic cells (400×) Fig. 11.2 Lymphoplasmacytic lymphoma from Fig. 11.1 showing the…
Cutaneous T-Cell Lymphoma
Indolent subtypes Frequency (%) Aggressive subtypes Frequency (%) Mycosis fungoides variants and subtypes 61 Sézary syndrome 4 Folliculotropic mycosis fungoides 6 Adult T-cell leukemia/lymphoma <1 Pagetoid reticulosis <1 Extranodal NK/T-cell…
Primary Cutaneous B-Cell Lymphomas
T T1: Solitary skin involvement T1a: A solitary lesion <5 cm diameter T1b: A solitary >5 cm diameter T2: Regional skin involvement: multiple lesions limited to one body region or…
Extranodal NK/T-Cell Lymphoma, Nasal Type
Fig. 7.1 (a) Extranodal NK/T-cell lymphoma of the nasal cavity. Small- to medium-sized tumor cells are intermingled with plasma cells. (b) EBER in situ hybridization revealed positive signal in the…
HIV-Associated Lymphomas
Fig. 12.1 Burkitt lymphoma. (a) In this example of a Burkitt lymphoma arising in the gastric wall of an HIV-positive patient, the tumor cells are slightly larger and more pleomorphic…
Primary Mediastinal Large B-Cell Lymphoma
Fig. 10.1 Primary mediastinal B-cell lymphoma: (a) H&E staining, consists of the neoplastic large cells with clear cytoplasm, (b) fibrotic bands with compartmentalising alveolar fibrosis, (c) tumour cells express CD30…
